Amikacin Injection: Uses, Side Effects & Dosages

Amikacin injection is a product of Cadila Pharma. It is used to treat various kinds of gram-negative bacterial infection, urinary tract infections, skin infections and lung infections. It is also prescribed for other ailments such as joint infections.

Amikacin Overview:

Amikacin injection inhibits the protein synthesis and stops the infection spreading and growth of the bacteria. It can battle infections caused by E.coli, Streptococci, and Enterococci in lungs, skin, abdomen and blood.

Uses and benefits Amikacin:

Amikacin injection is used to prevent and cure a number of ailments, their associated symptoms and any resultant medical conditions. It helps in both curing and preventing diseases such as:

  • Urinary Tract Infection
  • Skin Infection
  • Infection of Lining of Brain and/or Spinal Cord of Newborn
  • Pneumonia in newborn babies
  • Bacterial sepsis
  • Diverticulitis
  • Pseudomonas Aeruginosa Abdominal Cavity Lining Infection
  • Infection in abdomen
  • Burn wound infection
  • Bacterial Meningitis
  • Bacterial Blood Infection
  • Joint Infection
  • Bone Infection
  • Infection of the Biliary Tract
  • Blood or Tissue Infection in a newborn
  • active tuberculosis
  • Inflamed Colon and Small Intestine
  • Cystic Fibrosis
  • Pediatric Fever without a Source
  • Group B Streptococcal Sepsis

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Side Effects of Amikacin:

Like a lot of medicines, Amikacin injection can result in a few side effects.  The following are certain effects that can occur after this injection is taken by the patient:

  • Emesis
  • Bone pain
  • Renal problems
  • Fever
  • Hearing loss
  • Loss of balance
  • Acute paralysis
  • Apnea
  • Rash
  • Headache

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Common Dosage of Amikacin:

This medicine is injected into the vein and muscle as directed by the physician. The standard dosage is every 8 hours but this can vary. The dosage depends on the patient’s weight and medical condition. This antibiotic should be taken at evenly spaced times to ensure maximum effectiveness. Please use this medicine until the prescribed amount is finished even if the symptoms cease to exist. Stopping the medicine might cause a bacterial outbreak and allow the infection to recur

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Composition and Nature of Amikacin:

Amikacin belongs to a drug group known as aminoglycoside antibiotics. Amikacin injection has Amikacin as its primary ingredient. The injection has 100 mg of Amikacin and the quantity of Amikacin differs based on the strength of the medicine.

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Related Warnings/Precautions/ When to avoid Amikacin?

There are a number of precautions that should be followed while taking Amikacin injection. If you are taking the injection yourself please learn the preparation and usage thoroughly from your pharmacist. Check the product carefully for any particles or discoloration. Please store the injection and the liquid carefully and ensure that it does not get destroyed.

The following points should be taken into account while taking the medicine:

  • Not recommended for patients with an auditory impairment
  • The patient must complete the entire prescribed course
  • The patient should not use the medication unless they have been diagnosed with a bacterial infection
  • Not recommended for patients with Hepatic impairment
  • Not recommended for patients with possible Clostridium difficile associated diarrhea
  • Not recommended for patients who are pregnant
  • Not recommended for patients with renal impairment
  • The patient must stay hydrated while using this injection
  • Patient must stop using the injection and consult a doctor the moment they notice severe or bloody diarrhea, vertigo, or changes in hearing
  • Not recommended for patients with sulfite allergy
  • The patient must ensure that the medicine does not get inside their eyes or nose or mouth.

Do not use this injection if you are suffering from any of the following:

  • Hypersensitivity to amikacin or any other aminoglycoside
  • hearing problems (including decreased hearing, deafness)
  • cystic fibrosis
  • kidney problems
  • myasthenia gravis
  • low blood minerals (including magnesium, potassium, calcium)
  • Parkinson's disease.

Please note that if you are taking live bacterial vaccines such as the typhoid vaccine, their effectiveness might be affected by your Amikacin usage. Also please inform your doctor about the other medications you use including prescription, over the counter drugs and herbal products. Elderly people are exposed to the risk of kidney damage as a result of this drug.

Substitutes of Amikacin:

Some of the known substitutes of Amikacin injection are:

  • Mikacin 500 MG Injection manufactured by Aristo Pharmaceuticals Pvt.Ltd
  • Bristokacin 500 MG Injection manufactured by Bms India Pvt. Ltd
  • Amee 500 MG Injection manufactured by Zydus Cadila
  • Amikef 500 MG Injection manufactured by Lupin Ltd
  • Akasyn 500 MG Injection manufactured by Glenmark Pharmaceuticals Ltd

Amikacin Interactions:

Amikacin injection can have conflicts with the following medicines:

  • Amphotericin B
  • Bacitracin
  • Cephaloridine
  • Cisplatin
  • Colistin
  • Diuretics
  • Ethacrynic acid
  • Furosemide
  • Other aminoglycosides
  • Other nephrotoxic drugs
  • Calcium-channel blockers
  • Carbamazepine

When used with the following medicines, Amikacin might increase the chances of kidney damage and hearing loss:

  • amphotericin B
  • cidofovir
  • Cisplatin
  • polymyxin B
  • Tobramycin
  • cephalosporins such as cephaloridine
  • nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen

Most antibiotics don’t affect hormonal birth control processes such as pills, patch or ring. However, a few antibiotics can interfere with their effectiveness. It’s recommended you consult your doctor about this.

How Amikacin Works?

Amikacin is an aminoglycoside, and it binds itself to the prokaryotic ribosome which in turn inhibits protein synthesis in the bacteria. It is bactericidal in vitro against Gram-negative and Gram-positive bacteria.

Frequently Asked Questions

1) Is Amikacin injection considered to be a habit-forming drug?

Ans: I n India, all habit-forming medicines are categorized under Schedule X or H. Please go through the product packaging carefully to assess whether the injection can be addictive or not.

2) How long should I apply the injection before I see a noticeable change?

Ans: Patients have said that the injection often shows visible improvement on the same day or within a day. This differs from patient to patient and the condition they are being treated for.

3) What is the ideal frequency for taking Amikacin injection?

Ans: The standard frequency depends on the particular patient. Commonly it is once a day or twice a day. You can discuss it with your doctor and figure out the frequency.

4) Can you stop the injection suddenly or should there be a gradual decline in usage?

Ans: It is recommended that you gradually stop taking the injection because suddenly stopping might cause adverse effects on the body

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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