Cefixime 200 MG: Uses, Side Effects & Dosage

Cefixime 200 mg is a third generation cephalosporin antibiotic. Administered orally, it comes in the form of capsules or suspension. It is used in the treatment of a spectrum of bacterial infections, including otitis media or middle ear infection, strep throat, urinary tract infection, gonorrhoea, Lyme disease, skin infections, tonsillitis and throat infections or bronchial infections. For gonorrhoea, generally a single dose of Cefixime 200 mg is prescribed.

Cefixime 200 MG Tablet

Composition of Cefixime 200 MG Tablet:

Cefixime 200 mg constitutes of chemical entity Cefixime which is the active ingredient. Fundamentally, the mechanism of the medicine includes breaking down the bacterial cell wall, hence stopping the growth of bacteria.

Cefixime 200mg Uses:

Cefixime 200 mg is an antibacterial medicine that is used for treating infections caused by a host of bacterial strains. It is prescribed for the treatment of the following conditions:

  • Otitis Media, an infection in the ear inflicted by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus aureus
  • Certain urinary tract infections
  • Sexually transmitted disease gonorrhoea
  • Lyme disease
  • The infection and inflammation associated to sinusitis.
  • Streptococcus pyogenes induced infections of the throat including tonsillitis and pharyngitis
  • Streptococcus pneumoniae and Haemophilus influenzae caused infection of the chest, upper respiratory tract and lungs including bronchitis, pneumonia
  • The drug is also used for the treatment of Typhoid

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Cefixime 200 MG Side Effects:

There are some possible side-effects associated with Cefixime. Many side-effects are possible but will not always occur. Some side-effects may be serious, if they exhibit unusual persistence.

The side-effects include of this cephalosporin antibiotic include:

  • Abdominal pain, upset stomach, persistent nausea and vomiting
  • Allergic reactions that occur in the form of skin rashes, swelling and breathing difficulty
  • Paleness of skin, yellowish eyes and unexplained exhaustion
  • Dark colour of urine and change in amount and frequency of urinary discharge which may be indicative of kidney –related problems
  • Increased susceptibility to bruising and bleeding
  • Frequent mood swings and confusion.
  • Signs of infection like sore throat, fever
  • A rare intestinal condition with early manifestation as diarrhoea caused by Clostridium difficile may surface. The condition may sometimes occur after several weeks or months of discontinuation of Cefixime.
  • Persistent diarrhoea or sightings of mucus or blood in stools must be brought to the physician’s notice.

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Cefixime 200 MG Dosage:

Cefixime 200 mg should be taken as advised by your physician. Self-administration of the medicine is not advised. It should not be chewed or crushed. It can be taken with or without food but at a consistent time every day.

If you miss a dose, then take it as soon as you remember. However, do not take a double dose if it is already time for your next dose.

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How does Cefixime Tablet works?

Cefixime 200 mg is a bactericidal medicine with Cefixime as the active ingredient which functions by rupturing the cell wall of the bacteria thereby causing its death. This is a third generation cephalosporin bactericidal which is effective in controlling the growth of the bacteria and spreading of the infection.

Precautions - When not to use Cefixime 200 MG Tablet?

  • Physician must be contacted if white patches inside the mouth, any marked change in vaginal discharge or aggravation of the symptoms are witnessed.
  • A critical allergic reaction to this drug is rare yet it is advisable to get medical consultation if signs of allergy such as rashes, itching/swelling of the skin, handicapping dizziness, and distressed breathing are observed.
  • Mucus or blood stained stools must be reported to the physician.

Any anti-diarrhoeal or narcotic pain killers must not be taken to alleviate the associated symptoms like Diarrhoea, cramps or abdominal pain, as they may worsen the condition if resulting from resistant bacterial infection.

Prior to taking the drug inform the doctor about pre-existing allergies. Allergy to penicillin and cephalosporin class antibiotics should also be reported to the doctor.

History of kidney ailments and colitis should be reported to the doctor before starting the course of the medicine. The drug may interfere with the functioning of bacterial vaccines, inhibiting their efficacy. Vaccinations/ immunizations should not be done unless expressly told by the physician. The doctor should also be informed about the prescription medication, over-the -counter medicines, and also any herbal products being used for therapeutic or prophylactic purposes.

During pregnancy, the drug must be consumed only after the consultation of the doctor. Use of medicine in lactating mothers is on the discretion of the doctor. Benefits of the medicine must be weighed against the risks of administration.

Cefixime Substitutes:

The following are common substitutes for Cefixime:

  • Mahacef Mankind Pharma Ltd
  • Taxim Alkem Laboratories Ltd

Cefixime 200 MG Tablet Interactions:

There are certain drugs which may interact undesirably with Cefixime, with varying degree of severity. Vaccination, especially, must be continued with Cefixime only after the advice of the doctor.

Medicines and medical conditions the antibiotic may interact with include:

  • Cholera vaccine live
  • Gentamicin
  • Streptomycin
  • Kanamycin
  • Mycophenolic
  • Netilmicin
  • Nimodipine
  • Amikacin
  • Ampicillin
  • Anisindione
  • Bumetanide
  • Chloramphenicol
  • Colchicine
  • Drospirenone
  • Entecavir
  • Colitis- Cefixime should be carefully prescribed to patients with a history of Colitis given the fact that Pseudomembranous colitis does interact with most antibacterial agents. Interactions can be mild or potentially lethal.
  • Renal Dysfunction- Beta-lactam antibiotics including this drug are excreted by the kidneys as unaltered drug or metabolite. In the patients with kidney dysfunction, the serum concentrations of these excreted antibiotic and metabolites may rise and their half-life extended.
  • Liver Disease- Hepatitis is seen to occur in patients due to certain cephalosporin antibiotics.  SGOT, SGPT, and alkaline phosphatase levels are also seen to rise.

As several cephalosporins anti-bacterial medicines are empirically alleged to cause seizures in patients susceptible to interaction.

Cefixime 200 MG Tablet-FAQs Answered

1) Is Cefixime anti-diarrhoeal?

Ans: The drug is not prescribed as an anti-diarrhoeal. Incidence of diarrhoea, before or after starting the antibiotic must be reported to the physician.

2) How safe is the drug for infants?

Ans: In the case of infants less than 6 months old and new-borns, the safety of cephalosporin has not been conclusively established.

3) Is Cefixime a penicillin variant?

Ans: Cefixime is not penicillin variant. It is a cephalosporin antibiotic which functions like   penicillin. Concurrent use must be discussed with the physician.

4) Does Cefixime cause diarrhoea?

Ans: Diarrhoea is a known side effect of Cefixime although it has been associated with higher doses. In case of dehydration, physician must be consulted.

5) Can Cefixime cause constipation?

Ans: It is unusual for the drug to cause Constipation. In case it persists and seems circumstantially related to the intake of drug, consult the doctor.

6) Are pseudomonas susceptible to Cefixime?

Ans: No, Cefixime does not cover pseudomonas and its strains are resistant to the drug.

7) Is Cefixime prescribed for syphilis?

Ans: No, Cefixime does not cover Treponema pallidum, the causative agent of syphilis.

8) Can Cefixime be used to treat typhoid?

Ans: Cefixime is not indicated for the treatment of typhoid as such but Indian Academy of Paediatrics sanctions the use of Cefixime for treating uncomplicated typhoid fever in children.

9) Does Cefixime influence contraception?

Ans: There exists no evidence to suggest the effect of the drug on contraceptive medicine.

10) Can I take Cefixime with azithromycin?

Ans: Interactions have not been clinically observed between Cefixime and Azithromycin yet. Doctor’s consultation is advisable before consuming these medicines together.

11) Can Cefixime and doxycycline be taken together?

Ans: Interactions have not been clinically observed between Cefixime and doxycycline yet. Doctor’s consultation is advisable before concurrent use.

12) Can I take Cefixime with acetaminophen?

Ans: Interactions have not been clinically observed between Cefixime and acetaminophen (Paracetamol) yet. Doctor’s consultation is advisable before concurrent use.

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Last updated on : 01-04-2019

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