Cefoperazone Sulbactam: Uses, Side Effects, Composition, Dosage & Price

Cefoperazone Sulbactam belongs to the category of a third-generation cephalosporin antibiotic. It is used in the treatment of bacterial infections of the skin, urinary tract, respiratory tract, skin structures and genealogical infections, etc. The medicine is manufactured by Biocon Limited. The medicine is a prescription based drug and should only be taken after consulting a medical practitioner. The medicine should only be taken if an individual is sure of bacterial infection; or else it may result in development of drug resistant bacteria. The medicine contains Cefoperazone and Sulbactam sodium as its main ingredients. These drugs blocks the synthesis of bacterial cell walls hence inhibits further development of bacteria.

Nature: Antibiotic
Composition: Cefoperazone and Sulbactum sodium
Uses: Skin infection, urinary tract and respiratory tract infections
Side-effects: Nausea, Vomiting and Headache
Precautions: Patients with liver and kidney impairmentsshould use it with caution.

Uses and Benefits of Cefoperazone Sulbactam:

The medicine is used for the treatment and prevention of following conditions and symptoms:

  • Respiratory Tract infection: Cefoperazone Sulbactam is used in the treatment of respiratory tract infections caused by several bacteria including E. coli, Proteus mirabilis, Staphylococcus aureus, S. pneumoniae, Klebsiella species, Hemophilus and Enterobacter species.
  • Urinary Tract infection: The medicine is used in the treatment of Urinary tract infections caused by Pseudomonas aeruginosa and E.coli bacteria.
  • Bacterial Septicemia: The condition is explained as blood poisoning caused by Klebsiella species, S. pneumoniae and E. coli bacteria.
  • Cefoperazone Sulbactam is prescribed for the treatment of the condition.
  • Skin and skin structure infection: It is defined as the infection associated with soft tissues caused by bacteria. The infection is usually caused by Pseudomonas aeruginosa and Staphylococcus aureus (penicillinase producing and non-penicillinase producing species).
  • Gynecological infections: The infections include endometriosis and pelvic inflammatory diseases that are caused by epidermis, anaerobic gram-positive cocci and E.coli bacteria.
  • The medicine is found to be effective in such conditions.

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Side Effects of Cefoperazone Sulbactam:

Apart from the intended effects, use of this medicine may result in undesired effects. These side effects depend on several conditions such as clinical conditions, ongoing medications and age.

Listed below are the possible side effects of using this medicine:

  • Seizures
  • Nausea
  • Vomiting
  • Itching
  • Rash
  • Diarrhea
  • Itching or rash
  • Pseudomembranous colitis
  • Headache
  • Fever
  • Chills
  • Alterations in the blood count
  • Hypersensitivity
  • Unusual bleeding
  • Neutropenia

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Common Dosage of Cefoperazone Sulbactam:

  • The dose of medicine is prescribed on the basis of age, clinical condition, disease, severity and reaction to the first dose.
  • The prescribed dose should be strictly adhered to.
  • For adults, the usual recommended dose is 1 to 2 gm twice on the daily basis. In case of severe infections, the dose is increased to 3-4 gm thrice a day.
  • The medicine should be given to children only after consulting a medical practitioner.
  • In case of a missed dose, the medicine should be taken as soon as one remembers about it. However, if it is already the time of next dose it is advised to continue with the usual schedule.
  • An individual should not overdose to compensate for the missed dose. Overdose of the medicine may result in severe side effects such as diarrhea , blood in urine, vomiting, nausea and upper abdominal pain.
  • In case of overdose, it is advised to seek medical help without any delay.

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Composition and Nature of Cefoperazone Sulbactam:

The medicine contains Cefoperazone and Sulbactam sodium as its main ingredients.

  • Cefoperazone: It is semi-syntheticbroad spectrum cephalosporin antibiotic.
  • Sulbactam sodium: It is a derivative of penicillin.

Both drugs are intravenous medicines and acts as beta-lactamase inhibitor. This helps in increasing the antibacterial activity of Cefoperazone resistant organisms.

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Precaution and Warning - When to Avoid Cefoperazone Sulbactam?

  • Use of Cefoperazone Sulbactum should be avoided by pregnant women, unless deemed absolute necessary. A doctor should be consulted and risks and benefits should be calculated before starting the course of this medicine.
  • The medicine can be used by breastfeeding women. However, a doctor should be consulted before doing so. Also, the breastfed infant should be closely monitored.
  • The medicine should not be used by patients with a history of allergy to the medicine or any medicine belonging to the class of beta-lactam and Cephalosporin.
  • Use of Cefoperazone should be avoided if an individual is not sure of bacterial infections. Taking the dosage of Cefoperazone Sulbactum irrationally may fail in providing the desired result or may result in increased levels of toxicity in the body.
  • It is advised to inform the medical practitioner about existing or history of liver diseases including jaundice .
  • Level of Prothrombin should be measured regularly in patients who are on Cefoperazone Sulbactam therapy.
  • Prolonged use of Cefoperazone may result in overgrowth of non-susceptible organisms.
  • It is advised to assess the organ system dysfunction if Cefoperazone Sulbactum is prescribed for longer duration.

A doctor should be consulted immediately if any undesired effects such as nausea, vomiting, swellings of hands, feet and lips are experienced.

Also, it may result in the development of drug resistant bacteria.

Substitutes of Cefoperazone Sulbactam:

The medicine is available under different banner with same ingredients and strength:

  • Fytobact 500/500mg Injection 1'S manufactured by Cadila Pharmaceuticals Ltd
  • Omnibact 1gm Injection 10ml manufactured by Aristo Pharmaceuticals Pvt Ltd
  • Imex 1gm Injection manufactured by Dr. Johns Laboratories Pvt Ltd
  • Zostum 1gm Injection manufactured by Zuventus Healthcare Ltd
  • Augcef 500/500mg Injection 1'S manufactured by Wanbury Ltd
  • Magnex 1gm Injection manufactured by Pfizer Limited
  • Kefsurge 500/500mg Injection 1'S manufactured Indoco Remedies Ltd
  • Iszu Injection 1's manufactured by Aamorb Pharmaceuticals Pvt Ltd
  • Cemax 500/500mg Injection 10ml manufactured by Wanbury Ltd
  • Cefactam 1gm Injection manufactured by Veritaz Health Care Ltd

Cefoperazone Sulbactam Interactions with Other Drugs:

Use of Cefoperazone Sulbactam with certain drugs or in case of a few clinical conditions may result in interaction. This interaction can lead to undesired effects such as worsening of present medical condition, neutralization of effect of either of the medicines, etc.

Here is list of possible interactions:

Drug interactions

Use of Cefoperazone Sulbactam with other medicines may result in unwanted effects. Hence, it is advised to inform the medical practitioner about ongoing drugs in advance.

  • Loop diuretics: Use of Cefoperazone Sulbactam simultaneously may result in the destruction of hair cells in the organ of corti (chief part of ear). To avoid such situations, either of the medicines should be replaced with a suitable substitute.
  • Aminoglycoside antibiotics: Use of both drugs at a time may result in interference with the absorption of Cefoperazone Sulbactam. The interaction may also lead to undesired effects. The dosage should be adjusted of either of the medicines. Also, health conditions should be monitored during the course of medicine.
  • Anticoagulants: Use of any anticoagulants along with Cefoperazone Sulbactum may increase the risk of bleeding. It is advised to inform the doctor about the use of anticoagulants in advance. The dosage should be adjusted for either of the medicines and health condition should be monitored. In case any undesired effect is experienced, then it should be reported to a doctor without any delay.

Alcohol interaction

Use of Cefoperazone Sulbactam within 48-72 hours of consumption may result in hypersensitivity to alcohol. This can lead to abdominal pain, headache, vomiting, sweating, palpitations , increased heart rate and difficulty in breathing.

Consumption of alcohol should be avoided during and after the course of medication, as it can interfere with the desired result.

Any unusual effect should be reported to a medical practitioner, without any delay.

Disease interactions

Use of Cefoperazone Sulbactam in case of certain medical condition may result in worsening of the condition or lead to undesired effects. Hence, it is advised to inform the doctor about all medical conditions (existing or history of it).
Here is list of diseases which is reported to interact with Cefoperazone Sulbactum:

  • Clostridium difficile-associated Diarrhea: Use of Cefoperazone Sulbactum should be stopped if an individual experiences severe diarrhea after consumption. The condition occurs due to imbalance in the normal microbial flora caused due to antibiotic therapy in the large intestine. This promotes the growth of bacterial called as Clostridium difficile and reduces gut friendly bacteria, leading to diarrhea.
  • Liver impairment: Extreme caution should be practiced while using Cefoperazone Sulbactam by an individual who have active or known history of liver diseases. The medicine is excreted through bile; hence, level of Cefoperazone Sulbactum may increase. 4gms of this medicine is recommended for such patients. If the dose is exceeded more than 4gms, then serum concentration as well as liver functioning should be monitored closely.
  • Kidney Impairment: It is advised to practice extreme caution by patients with kidney diseases. Dosage should be adjusted appropriately on the basis of CrCl (Creatinine Clearance).

Lab interactions

Presence of Cefoperazone Sulbactam in the blood may interfere with the result of the certain tests.
Here is a list of lab tests which should not be conducted after taking Cefoperazone Sulbactam:

  • Benedict’s or Fehling’s Test: The test is moderately affected by the use of the medicine. Use of Cefoperazone may lead to a false positive result for glucose in the urine with the Fehling’s or Benedict’s reagent. To avoid any such circumstance, a medical practitioner should be informed in advance regarding the use of Cefoperazone Sulbactum. However, under no circumstance use of Cefoperazone Sulbactum should not be stopped without consulting a doctor.
  • Coomb’s Test: The result of the test is moderately affected by the presence of Cefoperazone Sulbactum in the blood. Coomb’s test helps detect anemia that is caused due to excessive destruction of red blood cells.

The lab practitioner should be informed about the ongoing medications before taking the tests.

Use of Cefoperazone Sulbactum should not be stopped without consulting a medical practitioner.

Cefoperazone Sulbactam Price in India:

Medicine Price
1.5 gm of Injection INR 35

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How Cefoperazone Sulbactam works?

Cefoperazone belongs to the group of antibiotics and acts as bactericide. The drug inhibits the synthesis of cell wall of bacteria and hence the medicine helps destroy the bacteria. The action is irreversible in nature. Sulbactum belongs to the category of beta-lactamase inhibitor drug and it works by creating an irreversible inactivation of β-lactamases.

How to use Cefoperazone Sulbactam?

The medicine is available in intravenous form and should be injected only by a health care professional.

When Cefoperazone Sulbactam is prescribed?

The medicine is prescribed in following conditions:

  • Meningitis
  • Septicemia
  • Bone and joint infections
  • Intra-abdominal infections
  • Pelvic inflammatory disease
  • Peritonitis
  • Surgical infections
  • Endometritis

Medicine that should not be taken with Cefoperazone Sulbactam:

  • Amikacin
  • Allopurinol
  • Probenecid
  • Tetracycline
  • Gentamicin
  • Tobramycin

How to store Cefoperazone Sulbactam?

  • The medicine should not be stored below 25 °C.
  • The medicine should not be exposed to heat and light; unless asked to do so.
  • The place of storage should be away from the reach of children and pets.
  • The intravenous solution can be reconstituted. The solution is found to be stable for around 7 days, if stored at a temperature of 2-8°C.
  • The unused and expired medicine should be discarded properly. Disposal instructions should be asked from a pharmacist.


1) What is the medicine used to treat?

Ans: The medicine is used in the treatment of bacterial infections such as skin, urinary tract, respiratory tract and gynecology.

2) How Cefoperazone injection works?

Ans: Cefoperazone belongs to the category of third-generation cephalosporin antibiotic. It inhibits the growth of cell wall of bacteria and hence, mitigates the growth of bacteria which is causing bacteria.

3) Are there any side effects associated with the use of Cefoperazone Sulbactum?

Ans: Yes, there are certain side effects associated with the use of Cefoperazone Sulbactum. However, it depends on certain factors such as age, clinical condition and ongoing medications.

Some of the commonly reported side effects include nausea, vomiting, headache, fever, chills and diarrhea.

4) What is the role of Sulbactam?

Ans: Sulbactam belongs to the category of β-lactamase inhibitor. It is a combination of β-lactam antibiotics and is helps inhibit β-lactamase. It is an enzyme that is produced by bacteria that destroys the antibiotics.

5) Is it safe to use during pregnancy?

Ans: The drug should be used in pregnancy only if it is necessary. A medical practitioner should be used only after consulting a medical practitioner.

6) What happens if somebody overdoses on Cefoperazone Sulbactam?

Ans: Overdose of the Cefoperazone Sulbactam can result in adverse effects. Also, the medicine should always be injected by a medical practitioner.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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