Crocin Advance Tablet: Uses, Side Effects, Composition, Dosages & Price

Crocin Advance is a mild analgesic that is used as a pain reliever for treating conditions such as headache, arthritis and dental pain. It is also given to cancer patients who have undergone surgery as it helps them in coping with pain.

Nature of Crocin Advance: Analgesic
Uses of Crocin Advance: fever , headache and menstrual pain
Composition of Crocin Advance: Paracetamol
Side effects of Crocin Advance: Allergic reactions, swollen face, rashes and nausea
Precautions: Liver & kidney disorder, pregnancy, and malnutrition

Crocin Advance Tablet

Crocin Advance is India’s first Paracetamol tablet with optizorb technology. The Crocin is taken orally and it is also taken intravenously.

Uses and Benefits of Crocin Advance:

Crocin Advance is used in relieving pain that is associated with arthritis, headache and fever. It is used in treating the following conditions:

  • Fever: The Crocin provides temporary relief from fever without treating the underlying cause. Its active ingredient is used both for curing fever and pain.
  • Headache: Headaches are common in both adults and children. Crocin Advance provides relief against from mild to moderate pain, such as migraine, cluster and acute headaches. Crocin Advance Tablet is used to relieve acute headaches including a migraine. It can be taken in combination with caffeine and aspirin to relieve the pain.
  • Muscle Pain: Muscle pains are caused by overuse of muscles. These pains are accompanied by swelling and restricted movement of the muscles or ligaments. Crocin is used to relieve muscle pain associated with shoulder, neck and back.

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Side Effects of Crocin Advance:

The following is a list of potential side effects that can be from all the composite materials of Crocin Advance Tablet (Crocin Advance Tablet). This is not a comprehensive list. These side effects are possible but are not always experienced. Some side effects can be rare, but serious. If any of the following side effects are discovered, and if they do not subside, doctor should be consulted at the earliest.

  • Allergic reactions
  • Swollen face
  • Rashes
  • Shortness of breath
  • Nausea
  • Liver damage
  • Asphyxia
  • Abnormalities of blood cells
  • Liver toxicity
  • Chronic kidney disease

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Common Dosage of Crocin Advance:

Crocin Advance is usually taken when required. If the patient is taking the Crocin on a regular basis, then the missed dose should be taken promptly. You should not take the missed dose if it is time for taking the next dose.
In case of overdose, Crocin can cause harmful effects to the body. Some of the symptoms are decrease of appetite, nausea, stomach pain while late symptoms include yellowing of skin and eye, and dark color urine.

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Composition & Nature of Crocin:

Crocin contains Paracetamol as its active ingredient. It gets absorbed faster than the standard Paracetamol. The Crocin is mainly used to reduce the pain caused due to fever. It is also used by people with CVD or heart conditions, sensitive stomach and diabetes.

It is not addictive or habit-forming.

Crocin Advance Price in India:

  • Crocin 650 mg tablet:  27 INR
  • Crocin pain relief tablet:  57 INR
  • Crocin baby drops peppermint:  33 INR
  • Crocin cold & flu max tablet:  47 INR

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When Crocin Advance is prescribed?

The Crocin is prescribed in treating the following conditions:

  • Menstrual cramps: For temporary pain relief, you can take Crocin as its ingredient Paracetamol helps in relieving cramps. For better results, Paracetamol combined with caffeine is more effective than Paracetamol alone.
  • Post Immunization Pyrexia : Fever is the common complaint in adults and children. This can be due to variety of infectious illness, and after immunization. Crocin can be taken for treating pain and fever post immunization.
  • Arthritis : This condition affects up to 10% of men and 18% of women across the world. Crocin has been used for treating arthritis as it has fewer side effects. It provides effective pain relief for joint pain as long it is taken in the correct dosage.

How to use Crocin:

Crocin should be taken as per the doctor’s prescription. It shows best result when taken as soon as the pain is experienced. They may not show the result until the pain gets worse.

The Crocin can be taken with or without food. It is not advised to crush, chew or dissolve the medicine. The typical dose of the Crocin for adults is 1000 mg every 4-6 hours, while the maximum dose can go up to 4000 mg per day. It is mostly taken for 3 days in case of fever, and 10 days for curing pain.

If using the syrup form of Crocin, then measure the dose using a measuring cup or spoon. Before pouring it into the measuring device make sure to check the markings. Do not use a tablespoon as it can give an incorrect dose. If being used in intravenous form, it should be given every 4-6 hours. It is important to carefully examine the injection for any change in color or presence of particles. One should use the injection within hours after opening it.

How Crocin works?

Crocin works on the central nervous system. It prevents the release of prostaglandin that increases the pain and body temperature. It reduces the intensity of pain signals that is sent to the brain.

For adults, the general dose of Crocin Advance for treating fever and providing relief from pain is 325-650 mg tablets once in every 4 to 6 hours or 1000mg tablet once in every 6 to 8 hours.

It is advised to take the Crocin as per the doctor’s prescription and not to exceed the prescribed dosage. The effect of Crocin lasts for at least of 4-6 hours. When taken in the form of an intravenous injection, its effect starts in 5-10 minutes. For treating fever, it takes about 30 minutes to cure the pain.

Warnings/Precautions- When to avoid Crocin Advance?

  • Pregnancy - Crocin Advance is not recommended for use by pregnant women unless necessary and the benefits exceed the risks involved. Crocin is not known to cause any harm to the unborn baby, but should only be used after consulting a doctor.
  • Breast-feeding - Crocin is safe to use during breastfeeding. However, it is advised to consult the doctor before starting the medication. Monitoring the baby for any undesired side effects like skin rashes or diarrhea is advised.
  • Overdose - It is suggested to read the packaging in order to avoid overdose. An overdose of the Crocin may cause liver damage. Patients should seek medical attention if an overdose is suspected.
  • Liver Disease - Crocin should be taken with extra care if the patient is suffering from liver function impairment or active liver diseases. Close monitoring of liver function is necessary while taking Crocin. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the condition of the patient.
  • Chronic Malnutrition - Crocin should be used with caution in patients suffering from malnourishment due to the increased risk of severe side effects. Dose adjustments or replacement with a suitable alternative may be required in some cases based on the patient’s condition.

Substitutes for Crocin Advance:

Below is the list of medicines which have the same composition, strength and nature as that of Crocin Advance 500Mg Tablet, and thus can be used as substitutes.

  • Paratas 500Mg Tablet
  • Ifimol 500mg Tablet
  • Xypar Rapid 500Mg Tablet
  • T-98 500mg Tablet
  • Paciwel 500Mg Tablet
  • Babymol 500Mg Tablet
  • Paralab 500Mg Tablet
  • Reximol 500MG TABLET
  • Taurpol 500MG TABLET
  • Molfit 500mg Tablet
  • Xykaa Rapid 500MG TABLET
  • Paceross 500mg Tablet
  • Micromol Tablet
  • Eboo Kid 500mg Tablet
  • T-Nil 500MG TABLET
  • Disprin Plus 500Mg Tablet
  • Paraldim 500Mg Tablet
  • Xyfix Extend 500Mg Tablet
  • Paracold 500Mg Tablet

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Crocin Advance Interactions:

When a person takes more than one medicine or mixes it with food items or beverages, it increases the chance of drug interaction. Drug interactions can also be a result of consuming a medicine while suffering from a different condition altogether. Such drug interactions can reduce the action of the medicine or cause side effects.

Interaction with Alcohol:

Consumption of alcohol with Crocin can have a severe effect on the liver. Therefore, taking alcohol is not suggested during the course of the Crocin Advance as it may increase the risk of serious side effects such as dizziness, fatigue, rashes, nausea and fever etc.

Interaction with Medicine

  • Carbamazepine: The medicine should not be taken with Carbamazepine. If the patient is using either of the medicines, the doctor should be informed before starting the course of the medicine. Symptoms like fever, chills and skin rash should be reported right away.
  • Phenytoin: The co-administration of crocin advance and phenytoin is not recommended. Usage of either of the medicines should be reported to the doctor.
  • Sodium Nitrite: Crocin Advance combination should be avoided. Symptoms like discoloration of skin, headache, dizziness, irregular heartbeat should be immediately told to the doctor.
  • Leflunomide: If these medicines are taken together, they may interact and cause harmful effects. Usage of either of the drug should be reported to the doctor.
  • Prilocaine: There is a possibility that these medicines may interact. Patients should contact their doctor if they experience dizziness, headache and irregular heartbeat.

Disease interactions

  • Liver Disease: Crocin Advance should be used with extra care in patients with liver function impairment or liver diseases due to the increased risk of side effects. Close monitoring of liver function is necessary during the course of the treatment. Patients should report symptoms like nausea, rashes and dark urine, etc. to the doctor on priority. The replacement or adjustment of the dose with any suitable alternative is based on the severity of the patient’s condition.

Interaction with lab test

HIAA Urine Test: One may experience a false-positive result for this test if Crocin Advance is being consumed.

Variants of Crocin:

The following are the variants of the Crocin Advance:

  • Crocin pain relief tablet
  • Crocin 650 mg
  • Crocin baby drops peppermint
  • Crocin cold & flu max tablet
  • Crocin 240 DS suspension mixed fruit
  • Crocin 1000 mg

Crocin Advance Suspension form:

The suspension forms of the Crocin Advance are listed below:

  • Crocin 240 DS suspension mixed fruit: Crocin Advance is used for treating fever, ear ailments and headache in children. It is gentle on children’s stomach. It comes in different flavours such as peppermint, strawberry and mixed fruit.
  • Crocin 120: Due to its antipyretic and analgesic properties, this syrup provides relief in treating various ailments such as headache, fever and flu-like symptoms. It comes with a dosing device that helps in measuring the accurate dose. It is available in different flavours such as peppermint, strawberry and mixed fruit.

Medicines that should not be taken with Crocin:

Sometimes when two medicines are taken at the same time they affect the blood vessels of other medicines which may increase or decrease the effect of other medicine. Mentioned below is the list of medicines that should not be taken with Crocin Advance.

  • Anticoagulants: Crocin Advance may interact with anticoagulants such as warfarin and coumarins, which are used to increase the time it takes for the blood to clot. If these medicines are taken together it can lead to the risk of bleeding.
  • Metoclopramide: The co-administration of Crocin Advance and metoclopramide can cause a drug interaction. Metoclopramide, which is used to treating GERD, can increase the effects of Crocin Advance.
  • Domperidone: Crocin Advance may interact with Domeperidone, which is used to treat nausea which is a side effect of other medicines. Domeperidone can increase the effect Crocin Advance.
  • Cholesyramine: Patients should be cautious while taking Crocin Advance with Cholestyramine, which helps in controlling high cholesterol and treats itching caused by liver disease.
  • Imatinib: It is not recommended to use Crocin Advance with Imatinib.

Crocin Advance can interact with other medicines containing Paracetamol, ibuprofen combinations and cold and cough medicines. These medicines can increase the risk of an overdose of Paracetamol that can cause liver damage.

How to store Crocin Advance?

The Crocin Advance should be stored at a temperature 20-25°C (68-77°F), away from heat, moisture and light. Medicine should be kept away from the reach of children and pets.

Crocin Advance should be taken before or after Food?

It is safe to take the Crocin on an empty stomach. Patients should limit their intake of medicine to 10 times in a month. One should increase the water intake in order to avoid dehydration.

Is Crocin Advance Banned in India:

The Crocin Advance is readily available in India. Since it’s a prescription medicine it is not recommended to take without consulting the doctor .


1) What is the normal dosage of Crocin for children?

Ans: For mild to moderate pain, the usual dose for adult is 500-1000 mg per 4-6 hours till the symptoms cure. The maximum dose goes till 4000 mg/day.

To calculate the dosage for children, one should use weight based dose calculator to calculate the appropriate dose as per the child’s weight. For example:

Children (2-3 years, 24-35 lb/11-16 kg in weight)

  • Recommended: 160 mg every 4 hours till symptoms cure
  • Maximum: 800 mg/day

Children (4-5 years, 36-47 lb/16-21 kg in weight)

  • Recommended: 240 mg every 4 hours till symptoms cure
  • Maximum: 1200 mg/day

2) What painkillers can be taken with Crocin Advance?

Ans: Ibuprofen, aspirin, codeine and naproxen are some of the painkillers that can be taken with Crocin Advance. There are no harmful interactions between Ibuprofen and Crocin Advance.

3) In what medical conditions, crocin advance should not be used?

Ans: Crocin should not be used in the following conditions:

  • Allergy: Crocin Advance should not be used if you are allergic to Paracetamol or any other ingredients of the medicine.
  • Kidney Disease: Crocin Advance should not be used by patients suffering from kidney disease caused by excessive use of painkillers.
  • Liver impairment: Crocin Advance is not recommended for use in patients with severe liver diseases due to the increased risk of worsening of the patient's condition. In such cases, suitable dose adjustments and replacement with a suitable medicine is required depending on the patient’s condition.

4) Is it safe to take more than one dose of Crocin Advance in a day?

Ans: Crocin Advance is an analgesic that is used for treating fever, toothache and pain associated to muscles, back and head. The recommended dose of Crocin is 1000mg, every 4-6 hours in a day. Patients who are elderly and suffer from liver or kidney impairment may need to lower the dose. An overdose of Crocin occurs when its toxic levels increases. The symptoms of Crocin Advance overdose may include dizziness, abdominal pain and vomiting, dark urine, yellowing of the skin and white patches.

5) What special precautions should be followed while using Crocin?

Ans: Patients prescribed Crocin Advance should take the following precautions while taking the medicine:

  • Avoid using Crocin if you are allergic to its ingredients or drugs with similar salts.
  • One should not stop the course of the medicine on their own unless told by the doctor. As stopping the course of the medicine suddenly may cause the illness to reoccur.
  • Patients should be cautious while taking the medicine if they are suffering from kidney or liver impairment.
  • Maintain your children’s safety by keeping the medicine out of their reach.
  • Do not drive and operate heavy machinery as the medicine may blur your vision.
  • Avoid using the medicine during pregnancy as the safe use of the medicine is not yet found.

You are advised not to use the medicine if:

  • It has passed the expiry date of the medicine printed on the pack.
  • The packaging shows signs of tampering or becomes discoloured.

6) My doctor has prescribed me with Crocin Advance tablet to treat fever. Can I take syrup instead of that?

Ans: No, the dosage forms of the medicine are prescribed based on the health of the patient. Kindly speak to your doctor regarding the dosage form.

7) On what factors the medicine is prescribed?

Ans: The dose and frequency of the medicine is prescribed depending on the following:

  • Age and weight of the patient
  • Patient's condition
  • Health of the patient's liver and kidneys
  • Medicines prescribed by the doctor
  • Any other medicines and herbal supplements being used
  • Receptivity to the medicine

8) Can Crocin Advance be used for treating migraine?

Ans: Yes, Crocin Advance can be used for treating migraine. Crocin provides targeted pain relief from headache, migraine and muscle ache.

9) Can Crocin Advance be taken with aspirin and tramadol?

Ans: Yes, the medicine can be taken with aspirin and tramadol as there no drug interaction is found between these medicines.

10) What should I tell my doctor before starting the medication?

Ans: Before starting the medication, tell your doctor about the following:

  • Tell your doctor which other medicines, nutritional supplements and OTC products you are taking.
  • Speak to your doctor about your present medical condition. For example, if you are suffering from liver impairment or not.
  • Tell your doctor whether you are pregnant or planning pregnancy, or you are breastfeeding.

11) Is the medicine safe for pediatric use?

Ans: If you are giving the medicine to your child, make sure you use the medicine is to be used for children. Notify child’s weight, age or the right dose from the product. Carefully read the dosage section of the page to know the correct dosage for your child. Else, speak your doctor and follow their recommendation.

12) How should Crocin Advance be taken?

Ans: If you are taking the tablet form of the medicine, make sure you do not take food or any fluid 5 minutes before taking the medicine. Wash your hands before taking the medicine. Do not chew, crush or break the medicine. You are not allowed to drink water after taking the medicine.

If you are using rapidly-dissolving tablet form of the medicine, chew Crocin and allow it to dissolve in the mouth. Then you can swallow the medicine.

13) What is the minimum dosage for Crocin pain relief tablet?

Ans: The minimum dose for children above the age of 12 years is 1-3 tablets in a 24 hour period as told by the doctor. The minimum gap between the two doses should be 4 hours.  Patients should take medical advice if they are suffering from liver or kidney impairment.

14) Is there any harm in taking multivitamins during the course of the treatment?

Ans: Yes, you can take multivitamins while taking the medicine as no interaction has been found between them. However, it does not mean that no interaction can ever happen. Therefore, patients should always speak to the doctor before starting the medication.

15) Can I use Crocin Advance to treat cough?

Ans: No, Crocin Advance is an analgesic that does not treat cough. However, in case of sore throat, it may be used as a pain reliever to manage pain in the throat.

16) Is Crocin Advance an anti-inflammatory drug?

Ans: Crocin Advance is an analgesic drug that may reduce pain. However, it does not show any effect on inflammation and thus it can’t be categorized as an anti-inflammatory


17) Should Crocin Advanced be taken before food or after food?

Ans: As the absorption of Crocin Advanced is not influenced by food, it can be consumed before or after having food, as advised by the doctor. However, to minimize its side effects, the patient should consider taking this medicine after having food. For case-specific recommendations, one must consult a doctor.

18) Is Crocin Advance banned in India?

Ans: No. Crocin Advance is not banned in India. However, it should be administered only after consulting a doctor.

19) Is Crocin Advance an antibiotic?

Ans: No, Crocin Advance is not an antibiotic. It is an analgesic that is used to temporarily relieve fever. It may also be used to treat mild to moderate pain.

20) Are Crocin and Crocin Advance same?

Ans: Both Crocin and Crocin Advance contain paracetamol in equal amount and are used as analgesics. However, unlike Crocin, Crocin Advance also contains super-disintegrants such as alginic acid and calcium carbonate. These ingredients make this medicine act within five minutes of consumption.

21) Can I consume Crocin Advance During Breastfeeding?

Ans: No, Crocin Advance is not safe to be consumed by nursing mothers. The medicine may adversely affect the health of the infant. The patient may consult a doctor for case-specific recommendations.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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