Dermi 5 Cream: Uses, Side Effects, Composition, Price & Dosage

Dermi 5 Cream is a topical medication cream which is used to treat various skin conditions. It is prescribed for itching, inflammations, eczema, rashes, dermatitis, etc. It contains topical preparations of a corticosteroid, an anti-bacterial agent, anti-fungal and an anti-protozoal agent. This combination helps in alleviating symptoms caused by a wide range of infections due to any micro-organism. Dermi 5 is manufactured by Universal Twin Labs and is an over the counter medicine. However, to avoid any undesired effects or interactions, a medical practitioner should be consulted in advance.

Nature of Dermi 5 Cream: Corticosteroids Anti-bacterial and Anti-fungal combination
Composition of Dermi 5 Cream: Clobetasol, Gentamicin, Tolnaftate, Clotrimazole, Clioquinol
Uses of Dermi 5 Cream: Eczema, Rashes, Itching, Inflammations
Side effects of Dermi 5 Cream: Burning sensation, severe itching, tingling sensation(Skin thinning)
Precautions: Should not be used on pimples, acne and sensitive skin
Dermi 5 Cream

Dermi 5 contains clobetasol which is a potent steroid typically prescribed by dermatologists for short duration . Prolonged use and applying on sensitive skin such face, genital areas, etc can lead to side effects. Therefore, this medicine should be used under doctor's advice.

Uses and Benefits of Dermi 5:

  • Skin Disorders: Dermatitis or inflammation of the skin arises due various local and systemic conditions. The symptoms include redness, rash, itching and mild swelling of affected area. Some of the common causes for dermatitis include eczema, psoriasis, allergy, drug reactions, and contact allergy after exposure to irritants or chemicals, etc. Clobetasol, the corticosteroid component of Dermi 5 ensures that the inflammation is brought down by acting against factors that cause redness, swelling and itching in the body. The anti-bacterial component, Gentamicin ensures that the raw area of the skin does not develop secondary bacterial infections. The other anti-fungal components in the drug prevent opportunistic fungal infection of the affected areas.
  • Autoimmune disorders: A disease in which the immune system attacks cellular components of one’s own body is called an autoimmune disease. These diseases have many skin manifestations which respond well to Dermi 5 application. Dermi 5 can be applied to affected skin areas in conditions such as alopecia areata, lichen planus, lichen sclerosis, etc.
  • Chronic skin conditions: Psoriasis is a chronic inflammatory skin disorder characterised by itchy lesions on the skin covered by shiny silvery scales. Lichen planus is also a chronic dermatologic disorder characterized by itchy, purplish-blue lesions. In both these conditions, Dermi 5 has shown to cause relief of symptoms.
  • Infections: Fungal infections like Ringworm infection, Athlete’s foot, jock itch, yeast infections and bacterial infections that cause pustules or blisters along with redness and inflammation can all be treated with topical application of Dermi 5 ointment. Infections spread due to multiplication of the offending organisms which form colonies and expand on the skin surface. Bacteriostatic agents in Dermi 5 preparation help to stop actively dividing micro-organisms from proliferating. Once the causative organisms are eliminated, the damage done can be easily brought down by the anti-inflammatory component of Dermi 5 ointment.

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Side Effects of Dermi 5:

Being a topical medication ointment, Dermi 5 is well tolerated by most patients and does not cause adverse effects. In very rare cases the following side-effects may occur if not used as advised by a doctor or if it is used for disorders where its use is not intended.

  • Dryness of skin
  • Burning sensation on applied surface of skin
  • Tingling sensation on skin
  • Increase in redness or itching
  • Headache
  • Body ache
  • Cough
  • Sore throat
  • Flu-like illness

The patient should be rushed to a registered medical practitioner for emergency medical care and supervision if severe allergic symptoms develop to any of the components of Dermi 5 such as:

  • Feeling of tightness of chest
  • Wheezing
  • Breathlessness
  • Fever
  • Severe itching
  • Swelling of vocal cords and inability to breathe
  • Bluish discoloration of skin
  • Severe fatigue
  • Severe cough
  • Rising fever with chills

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Common Dosage of Dermi 5:

The dosage should be followed as prescribed by a doctor/ pharmacist or as mentioned on the leaflet, if it is being taken as an over the counter medicine.Usually, Dermi 5 is applied twice a day on the affected area. In case of a missed dose, as soon as one remembers about the dose. However to compensate for the missed dose, Dermi 5 Cream should not be applied in excess.

Applying more than the prescribed amount or increasing the frequency might lead to undesired effects such as thinning of the skin, worsening of the condition or sometimes it may result in permanent damage. In case of overdose, a doctor or medical practitioner should be consulted immediately.

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Composition & Nature of Dermi 5:

Dermi 5 is a combination of 0.05%w/w of Topical Clobetasol propionate, 0.1%w/w of Topical Gentamicin, 1%w/w of Topical Clotrimazole, 1%w/w of Topical Clioquinol (Iodochlorhydroxyquin) and 1%w/w of Topical Tolnaftate. The ointment is rapidly absorbed from the site of application and acts quickly to bring down inflammation and swelling. The ointment is minimally absorbed and hence is generally tolerated well.

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Dermi 5 Price in India:

  • Dermi 5 mg (1 tube of 15 gm):  49.50 INR

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How Dermi 5 works? The whole process contributes to the reduction and prevention of the rashes, allergy, eczema, psoriasis and other autoimmune disorders.

The Dermi 5 belongs to the category of corticosteroids and works as an anti-inflammatory agent. It blocks the metabolism of arachidonic acid by obstructing synthesis of phospholipase A2. This results in the reduction in the production of inflammatory agents such as leukotrienes and prostaglandins.

Mechanism of Action of Clobetasol propionate

Clobetasol propionate is a highly potent topical synthetic glucocorticoid with excellent anti-pruritic and anti-inflammatory properties. It works by suppressing the action of inflammatory agents that cause built-up of fluid resulting in swelling, induration and redness. It suppresses tissue factors that cause increased itching in affected areas. It has vast-constrictive properties too that help to reduce redness, warmth and inflammation of afflicted areas.

Mechanism of Action of Gentamicin

Gentamicin is a topically effective antibiotic which works by interrupting protein synthesis in the causative bacteria. Thus, there is arrest in multiplication of bacterial organisms resulting in good antiseptic action.

Mechanism of Action of Clotrimazole

Clotrimazole is an azole anti-fungal which acts by interfering with the biosynthesis of ergosterol which is an essential component of fungal cell membranes. This results in stopping of fungal proliferation in affected sites.

Mechanism of Action of Clioquinol (Iodochlorhydroxyquin)

Clioquinol is a potent anti-bacterial, anti-fungal and anti-protozoal agent which acts as a topical antiseptic. The exact mechanism by which Clioquinol exerts its action is unknown.

How to use Dermi 5?

  • All the instructions mentioned on the leaflet should be followed strictly.
  • The Dermi 5 should be applied to the affected area.
  • If Dermi 5 is being used to treat diaper rash, the area should be cleaned and dried before applying Dermi 5.
  • If the cream is being used to treat radiation skin burns, then a medical professional should be consulted before applying Dermi 5.
  • Dermi 5 should is for external use only i.e. it should be applied to the skin.
  • Any kind of contact with sensitive areas such as eyes, nose, mouth, groin area, etc. should be avoided; unless asked to do so by a doctor.
  • Dermi 5 should be applied after showering/bathing when the skin is damp.
  • If skin where Dermi 5 should be applied is dry, then it is advised to soak the area before using the Dermi 5.
  • The Dermi 5 should not be applied on irritated, scrapped, chapped, cut, broken or recently shaved area of the skin; unless asked to do so.
  • If the conditions persist, worsen or result in other side effects then it is advised to consult a doctor as soon as possible.

When Dermi 5 Cream is prescribed?

The Dermi 5 is prescribed to treat following conditions:

  • Dermatitis
  • Psoriasis
  • Dry skin
  • Lichen planus
  • Inflammations
  • Eczema
  • Allergic reactions
  • Rashes
  • Redness on the skin
  • Itching
  • Vitiligo
  • Alopecia areata
  • Lichen sclerosus
  • Diaper rash
  • Skin burns
  • Radiation therapy
  • Flaking skin

Warnings/Precautions- When to avoid Dermi 5?

Dermi 5 Cream has no reported interactions with any other medication. The steroid component may increase the severity of Diabetes mellitus in patients diagnosed with the condition. Dose adjustment is required as the effects are directly proportional to the concentration of the steroid in the ointment applied. Consultation with a registered medical consultant is essential if Dermi 5 application is necessary in patients suffering from or is at high risk of developing Diabetes mellitus.

Research studies on animals have revealed adverse fetal effects on topical application of Dermi 5. Hence Dermi 5 is not recommended for use in Pregnant or lactating mothers unless the benefits substantially outweigh the risks. In any case, the ointment should be used only after consultation with a registered medical practitioner. Studies have shown that there is no significant interaction with alcohol intake. Dermi 5 topical cream application doesn’t significantly affect individuals with kidney or liver disorders.

Substitutes for Dermi 5 :

Decaderm Cream is the only substitute available in the market.

Dermi 5 Variations:

Dermi 5 has no different form

How to Store Dermi 5 Cream?

  • Dermi 5 should be stored in cool and dry place.
  • The temperature of the storage area should not exceed 49°C (120°F).
  • The Dermi 5 should not be exposed to direct heat and light.
  • The place of storage of Dermi 5 should be away from the reach of children and pets.
  • Dermi 5 should not be flushed or poured in the drain as doing so can pollute the environment.
  • If the Dermi 5 has expired or no longer of use, then it should be disposed properly. Disposal procedure should be asked from a pharmacist or a medical practitioner.


1) Is it safe to use Dermi 5 Cream on the face?

Ans: The Dermi 5 Cream should never be used on the face as it can cause pimples, pigmentation and thinning of the skin. It can make acne worse if it is present already. It is advised not to use any topical steroid without consulting a dermatologist.

2) What is Dermi 5?

Ans: Dermi 5 is potential corticosteroid which reduces the actions of chemicals responsible for redness, itching, inflammation, flaky skin, etc.

3) How Dermi 5 should be used?

Ans: The Dermi 5 is applied to the affected area, usually twice a day or as per the directions given by a doctor. The Dermi 5 should be applied to the skin. Interaction of cream with sensitive areas which includes the face, groin, underarms, etc. should be avoided. The amount used should not be used more or less than the prescribed amount.

4) Is Dermi 5 Cream effective in treating pimples?

Ans: The Dermi 5 should not be used in case of pimples, acne, fungal skin infections, etc. It is a steroidal cream with clobetasol as its main ingredient. Dermi 5 should only be used in thick skin areas and not on sensitive skin. Using Dermi 5 on sensitive skin can cause thinning of the skin and the skin can be damaged permanently. It is advisable to consult a doctor if anything as such happens.

5) What precautions should be followed while using Dermi 5 ?

Ans: It is advisable to inform the doctor in advance about the health conditions (including pregnancy and breast-feeding). Dermi 5 should not be applied on nipples, if the woman is breastfeeding. Dermi 5 should not be applied to broken skin, infected skin or skin that is discharging pus or fluid. Dermi 5 should not be applied on face, armpits or groin, unless asked by a doctor.

6) How Dermi 5 Cream should be stored?

Ans: The Dermi 5 Cream should be stored at room temperature. The place of storage should be cool, dry and away from the reach of children and pets.

7) What is Dermi 5 used for?

Ans: The Dermi 5 Cream is used in the treatment and prevention of conditions such as inflammations, itching, redness, eczema, psoriasis, dermatitis, allergic reactions, etc.

Apart from the above-mentioned conditions, Dermi 5 is used in the prevention and treatment of autoimmune diseases which includes lichen sclerosus, vitiligo, alopecia areata, lichen planus, etc.

8) How does Dermi 5 Cream work?

Ans: The Dermi 5 Cream belongs to the category of Corticosteroids. It works as an anti-inflammatory agent by blocking the synthesis of phospholipase A2. It blocks the metabolism of arachidonic acid and therefore blocks the production of inflammatory agents such as leukotrienes and prostaglandins.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

User Comments (4)



Thu Feb 07 2019

Is Dermi 5 Cream is a skin lightening cream?



Thu Feb 07 2019

Will the Dermi 5 Cream helps in curing pimple?



Thu Feb 07 2019

Can I use Dermi 5 Cream for a fungal infection outside vaginal area?


Nipa das

Sat Jul 13 2019

Dear dr.sompraz 40. i had taken this madicine already 2 years,bt dr said to continiu only 3 mnths,bt wheb I stop this i feel sick nd pblm of gas,,so now can i continiu this madicine?


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