Lanol ER is an anti-inflammatory drug which is used commonly to treat mild to moderate pain and fever in many disease conditions. It is the most commonly used medication to treat pain and fever the world over. It is enlisted in the World Health Organization’s (WHO) list of essential medicines which includes the most effective and safe medications required for a health system.
Lanol ER can be used effectively to relieve symptoms in many disease conditions
Lanol ER is generally well tolerated. Different individuals react differently to the drug and hence minor side-effects may occur. These include
The above mentioned minor side-effects are usually transient and disappear when the drug is discontinued.
Very rarely, adverse side-effects may occur in certain susceptible individuals.
The patient should be immediately taken to the nearest emergency care unit if the following are encountered:
The list is not conclusive and may include other possible side-effects for which a doctor should be consulted.
The drug is best taken after consultation with a registered medical practitioner.
For adults, Lanol ER can be given in doses of 500mg - 1 g every 4-6 hours. A maximum of about 4g only can be given in one day. Administration of the drug more than the recommended dosage causes severe toxicity.
Symptoms of overdosage include:
The dose is adjusted in chronic alcoholics, known G6PD deficiency, chronic malnutrition and in patients with severe hypovolemia.
Each tablet of Lanol ER contains 650 mg of Paracetamol/Acetaminophen.
Paracetamol is an analgesic and antipyretic. After oral ingestion, the drug is rapidly absorbed by the gastrointestinal tract. It is primarily metabolized by three distinct metabolic pathways in the liver. The final end products are excreted through the kidney.
The consulting physician should be informed about the previous health condition of the patient along with present health condition and drugs currently taken, whether allopathic or alternative medicine therapy. This is very important because the physician adjusts the dose according to the condition of the patient and may be able to warn about possible side effects to look for in specific conditions.
Caution is required in patients with liver diseases, kidney diseases or abnormal liver and kidney function tests. Since Paracetamol is primarily metabolized in the liver and kidney, a compromised liver or diseased kidney cannot effectively get rid of the by-products of paracetamol metabolism and may lead to exaggerated side effects and poor patient tolerance.
Though no adverse effects have been recorded, Lanol ER use in pregnancy and lactation should be done after consultation with a general physician or obstetrician.
Lanol ER is seen to interact with a few other medications like Carbamazepine, Phenytoin, Sodium nitrite, Prilocaine, Leflunomide, etc. Patients taking these drugs need to inform their doctor who will offer advice on dose adjustments.
Mechanism of Action of Lanol ER
The analgesic action of Lanol ER is by peripheral blockage of generation of pain impulses. It results in antipyresis by inhibiting the hypothalamic heat-regulating center. Paracetamol/Acetaminophen appears to act by reducing the quantity of cyclo-oxygenase which needs to be oxidized in order to function as inflammatory mediators. Thus its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS. It also acts by modulating the endogenous cannabinoid system within the central nervous system.
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