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Lonazep Tablet: Uses, Side Effects, Composition & Dosages

Lonazep is an anxiolytic and an anticonvulsant drug which belongs to the benzodiazepine group of sedatives. It is used for the management and treatment of conditions such as epilepsy, seizures, akasthesia, panic disorder, anxiety, panic attacks, certain phobic reactions and insomnia. The medicine is also used for the treatment of symptoms of behaviour or motor function abnormality such as acute catatonic reactions and involuntary movement disorders. Lonazep is manufactured in India by the Sun Pharmaceutical Company.

Nature anxiolytic and an anticonvulsant
Composition Clonazepam
Uses Seizures, anxiety, depression
Side-effects Dizziness, drowsiness, constipation, urinary retention
Precautions Kidney and liver-related problems, Closed Angle Glaucoma, Respiratory disorders, Obesity

Lonazep Tablet

Uses and Benefits of Lonazep:

Besides being an anticonvulsant medicine, Lonazep is also an anxiolytic and sedative. The medicine is usually prescribed for the treatment and prevention of conditions such as -

  • Seizures
  • Panic disorder and social phobia with or without agoraphobia
  • Movement disorder (akathisia)
  • Anxiety and depression comorbidity
  • Insomnia
  • Post-Traumatic Stress Disorder
  • Alcohol withdrawal symptoms or delirium tremens
  • Akasthisia, a movement disorder

Read More: Pantoprazole Uses | Omnacortil Uses

Side Effects of Lonazep:

Some of the side effects associated with the consumption of Lonazep tablets are -

  • Dizziness
  • Drowsiness
  • Confusion
  • It may interfere with memory
  • Erectile dysfunction
  • Constipation
  • Urinary retention
  • Dependence
  • Withdrawal symptoms

Read More: Ibugesic Plus Side Effects | Supradyn Side Effects

Common Dosage of Lonazep:

Dosage for seizure disorders -

Dosage for adults

  • The doctor may prescribe an initial dosage of 0.5 to 1 mg to be taken once in 3 days. The dosage may also be increased to 1.5 mg per day, divided into three doses.
  • A maximum dosage of 20mg/day may be prescribed in severe conditions.

Dosage for children

  • An initial dosage of 0.25 mg/day may be prescribed by the doctor.
  • For children between the ages 1-5, a dose ranging between 1-3 mg per day may be prescribed.
  • For children between 0-1 years, a dose of 0.5-1 mg per day may be prescribed.

Dosage for the elderly

  • The doctor may prescribe an initial dose of 0.5 mg per day which may be slowly increased depending upon the patient's condition.

Dosage for Panic attacks

  • Depending upon the age and condition of the patient an initial dose of 1mg/day may be prescribed to the patients. The doctor may increase the dose to a maximum of 4 mg per day.

Missed Dose

  • If a patient misses a dose of Lonazep tablets, it must be taken as soon as the patient remembers about it. However, if it is almost the time to consume the next dose, the previous dose must be skipped. Patients are advised not to consume two doses to compensate for the missed dose.

Overdose

  • Administering more than the prescribed dose of the medicine may lead to severe side effects such as confusion, drowsiness, involuntary movement of the eye, low blood pressure, slurred speech etc. If an overdose is suspected, the patient must immediately consult a doctor.

Read More: Tryptomer Dosage | Cremaffin Dosage

Composition and Nature of Lonazep:

Lonazep is an anxiolytic and an anticonvulsant drug which contains Clonazepam which is a benzodiazepine variant. It functions by manipulating the signalling and reception of neurotransmitters in the area of the brain to arrest seizures and also to alleviate anxiety. Clonazepam can cross the blood-brain barrier and it is a Central Nervous System (CNS) depressant.

Read More: Cyclopam Composition | Norflox TZ Composition

How to use Lonazep Tablets?

  • The medicine must be taken in time and duration as prescribed by the doctor.
  • The tablets must not be chewed, crushed or broken before consumption.
  • The medicine can be consumed with or without food.
  • The medicine should be consumed at a fixed time.

How Lonazep Tablet works?

Lonazep’s constituent psychotropic clonazepam is a benzodiazepine. The medicine simply works by increasing the activity of a chemical messenger (GABA). This chemical subdues the abnormal and excessive activity of the nerve cells in the brain.

When is Lonazep prescribed?

The medicine is usually prescribed for the treatment and prevention of epilepsy and anxiety disorders.

Precautions and Warnings - When to Avoid Lonazep?

Following are the precautions and warnings that must be adhered to while administering Lonazep tablets –

  • The patients are advised to inform their doctor about any ongoing medicines and treatments.
  • Patients suffering from liver and kidney related ailments must consume medicine only on the advice of a doctor.
  • Patients sensitive to the ingredients of the medicine must not consume it.
  • Pregnant women must administer this medicine only if deemed absolutely necessary by a doctor.
  • Lactating mothers are advised not to consume this medicine as it may pass from the milk and harm the health of the baby.
  • Patients consuming other central nervous system depressants drugs must not consume this medicine.
  • Patients suffering from long-term pulmonary insufficiency are at increased risk of suffering from adverse side effects on consuming this medicine. Extra caution must be practised in such patients.
  • The medicine should not be administered by patients suffering from genetic disorders such as galactose intolerance and Lapp lactase deficiency.
  • Patients suffering from porphyria must not consume this medicine as it increases the risk of convulsions in such patients.
  • Patients must avoid driving immediately after the consumption of Lonazep tablets.

Substitutes of Lonazep:

The following are the substitutes of Lonazep tablets -

  • Rivotril 0.5mg Tablet manufactured by Abbott
  • Zapiz 0.5 Tablet manufactured by Intas Pharmaceuticals Ltd
  • Clonotril 0.5 Tablet manufactured by Torrent Pharmaceuticals Ltd
  • Epitril 0.5mg Tablet manufactured by Novartis India Ltd
  • Petril 0.5 Tablet manufactured by Micro Labs Ltd
  • Cloze 0.5mg Tablet manufactured by Talent India
  • Lonapam 0.5mg Tablet manufactured by Shine Pharmaceuticals Ltd
  • Klonaz 0.5mg Tablet manufactured by Kivi Labs Ltd
  • Clomid 0.50 Tablet manufactured by Midas Healthcare Ltd
  • Clonapax 0.5mg Tablet manufactured by Reliance Formulation Pvt Ltd
  • Emcloz 0.5mg Tablet manufactured by Emcure Pharmaceuticals Ltd
  • Ozepam 0.5mg Tablet manufactured by Ipca Laboratories Ltd
  • Restovis 0.5mg Tablet manufactured by Avis Lifecare Pvt Ltd
  • Clotas 0.5 Tablet manufactured by Tas Med India Pvt Ltd
  • Clonorest 0.5 Tablet manufactured by Altius Life Sciences
  • C Trika 0.5mg Tablet manufactured by Torrent Pharmaceuticals Ltd
  • Clozakin 0.5mg Tablet manufactured by Wings Biotech Ltd
  • Closed 0.5mg Tablet manufactured by Corona Remedies Pvt Ltd
  • Epcon 0.5mg Tablet manufactured by La Pharmaceuticals
  • Clonax 0.5mg Tablet manufactured by A N Pharmacia
  • Convaclon 0.5mg Tablet manufactured by Baroda Pharma Pvt Ltd
  • Linotril 0.5mg Tablet manufactured by Linux Laboratories
  • Clozy 0.5mg Tablet manufactured by Nusearch Organic
  • Zona 0.5 Tablet manufactured by Solvate Laboratries Pvt Ltd
  • Clopin 0.5mg Tablet manufactured by Kloster Pharmaceuticals
  • Caspa 0.5mg Tablet manufactured by Thrift Pharmaceuticals
  • Meloprax 0.5mg Tablet manufactured by Mankind Pharma Ltd Lonazep

Lonazep Tablet Interactions:

Interactions with drugs

Lonazep tablets may interact with anticonvulsants such as -

  • Hydantoins
  • Phenobarbital
  • Clonazepam
  • Carbamazepine
  • Phenytoin
  • Sodium valproate

Lonazep may interact with medicines such as -

  • Amprenavir
  • Cimetidine
  • Fluvoxamine
  • Disulfiram
  • Ritonavir
  • Primidone
  • Theophylline
  • Phenothiazines
  • Monoamine oxidase inhibitors
  • Tricyclic antidepressants
  • Moxonidine or alpha-blockers (medicines used to treat high blood pressure)
  • Nabilone
  • Tizanidine
  • Opioid analgesics
  • Mirtazapine
  • Lofexidine
  • Clonidine
  • Methyldopa
  • Diazoxide
  • Diuretics
  • Minoxidil
  • Nitrates
  • Nitroprusside

Lonazep may also interact with other medicines such as -

  • Propantheline - This medicine is used for the treatment of excessive sweating. When Lonazep is consumed along with Propantheline the level of Lonazep in the body decreases eventually leading to its reduced efficacy.
  • Ranitidine - This medicine is used to decrease stomach acid. When Lonazep is consumed along with Ranitidine, the activity of Lonazep is altered.
  • Rifampicin - The medicine is used for the treatment of tuberculosis. When Lonazep is used with rifampicin, the medicine may interfere in the metabolism of Lonazep.
  • Levodopa - When Lonazep is consumed with Levodopa, the effect of Lonazep gets reduced.

Interaction with alcohol

The medicine should not be consumed with alcohol because administering alcohol along with Lonazep tablets may increase the sedative and drowsiness effect on the patients.

Interaction with diseases

  • Closed Angle Glaucoma - Patients suffering from Closed Angle Glaucoma may suffer from severe side effects by administering the two medicines simultaneously.
  • Respiratory disorders - The medicine should be administered with caution in patients suffering from respiratory disorders. Careful monitoring and dose adjustments may be required in such patients.
  • Obesity - Patients who are obese must exercise extra caution while administering this medicine as it may lead to severe side effects.

Lonazep Tablet Variants

Following are the variants of Lonazep tablets –

  • Lonazep 0.5mg Tablet
  • Lonazep 2mg Tablet
  • Lonazep 0.25 Tablet
  • Lonazep 1mg Tablet
  • Lonazep MD 0.5 Tablet
  • Lonazep 0.25 Tablet MD
  • Lonazep 2mg Tablet MD
  • Lonazep 1mg Tablet MD

Medicines that should not be taken with Lonazep:

Lonazep tablets should not be consumed with the following medicines –

  • Amprenavir
  • Cimetidine
  • Fluvoxamine
  • Disulfiram
  • Ritonavir
  • Primidone
  • Theophylline
  • Phenothiazines
  • Mirtazapine
  • Lofexidine
  • Clonidine
  • Methyldopa
  • Diazoxide
  • Diuretics
  • Minoxidil
  • Nitrates
  • Nitroprusside

­­­

Lonazep Tablet Price in India:

Medicine name Manufacturer Price
Lonazep 0.5mg Tablet (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 50
Lonazep 2mg Tablet (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 89
Lonazep 0.25 Tablet (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 29
Lonazep 1mg Tablet (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 44
Lonazep MD 0.5 Tablet (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 33
Lonazep 0.25 Tablet MD (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 19
Lonazep 2mg Tablet MD (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 88
Lonazep 1mg Tablet MD (strip of 10 tablets) Sun Pharmaceutical Industries Ltd INR 44

Read More: Urimax Price | Uprise D3 Price

How to store Lonazep Tablet?

  • The medicine should be stored away from direct sunlight and heat.
  • It should be stored in a dry and cool place.
  • The medicine should be kept out of reach of pets and children

Lonazep Tablet FAQs

1) Is Lonazep safe to be consumed by pregnant women?

Ans: No, the medicine is not safe to be consumed by pregnant women. This is because the medicine poses a serious threat to the health of developing fetus. The medicine may be consumed by pregnant women only if deemed absolutely necessary by a doctor.

2) Is it safe to drive or operate heavy machinery after consuming Lonazep tablets?

Ans: No, it is not safe to drive or operate heavy machinery after consuming Lonazep tablets. This is because the medicine induces dizziness and drowsiness in the patients after being administered.

3) What will happen if I accidentally consume an expired dose of Lonazep Tablet?

Ans: Although it is always recommended to check the expiry date of the medicine before administering it, a single expired dose may not cause any severe side effects. It must be noted that the efficacy of the medicine may be affected as an expired tablet will not be as effective in treating the symptoms. In case of experiencing any severe side effects, a doctor must be consulted immediately to seek remedial action.

4) Should I administer Lonazep Tablet before or after having a meal?

Ans: It is commonly advised to consume the medicine after having a meal for maximum efficacy and increased the effect. For case-specific recommendations, it is advised to consult a doctor before starting the dose of the medicine.

5) Is this medicine habit forming?

Ans: Yes. The medicine does have habit-forming tendencies both physiological and psychological. Therefore, the medicine must be administered only for the period prescribed by the medical practitioner.

6) Can Lonazep be used for the treatment of insomnia?

Ans: Yes, Lonazep can be prescribed for the treatment of insomnia. The medicine belongs to a class of drugs known as Benzodiazepines which are used to treat various conditions such as anxiety and insomnia.

7) What will happen if I continuously forget to take Lonazep?

Ans: Missing a single dose of the medicine may not cause much effect. However, for a medicine to work properly some concentration of medicine should always be present in the body. If a patient continuously misses the dose of the Lonazep, the medicine may not be able to completely cure the condition it has been prescribed for.

8) What will happen if overdose on Lonazep tablet?

Ans: Taking more than the recommended dose of the medicine may lead to side effects such as confusion, drowsiness, involuntary movement of the eye, low blood pressure, slurred speech etc. In case of a suspected overdose, it is advised to consult a doctor to seek remedial action.

9) What are the common side effects associated with Lonazep Tablet?

Ans: The common side effects associated with Lonazep Tablet are dizziness, drowsiness, confusion, constipation etc.

10) Is Lonazep Tablet available as an Over- the- Counter medicine?

Ans: No, Lonazep is a prescription-only drug. The medicine is an anticonvulsant and is not available as an over the counter product.

11) Can I take Lonazep Tablet along with other antidepressants?

Ans: No, antidepressants are not recommended to be administered along with Lonazep Tablets as they may interact and lead to severe side effects when co-administered. A doctor must be consulted for before starting the dose of any medicine to avoid the occurrence of drug interactions.

12) Can I immediately stop the consumption of this medicine as soon as I see improvement in my conditions?

Ans: No, it is not advisable to abruptly stop or alter the dosage of the medicine even if an improvement in the condition is experienced. Leaving the course of medicine in between may not completely cure the condition it has been prescribed for. The doctor must be consulted before stopping the consumption of the medicine as he may prescribe an alternate dose if side effects persist.

13) What is Lonazep Tablet used for?

Ans: Lonazep Tablet is used to treat various types of seizure  and epileptic disorders such as, absence seizures (petit mal) including atypical absence seizures, akinetic and myoclonic seizures, Lennox-Gastaut syndrome (petit mal variant), various forms of myoclonic seizures, myoclonus and associated abnormal movements and primary or secondarily generalized tonic-clonic seizures (grand mal), partial (focal) seizures.

14) Can the consumption of Lonazep tablets lead to constipation?

Ans: Yes, constipation is a very common side effect associated with the use of Lonazep Tablets.  Patients are advised to visit a doctor if the pain persists for a prolonged duration.

15) Is Lonazep safe to be consumed by lactating mothers?

Ans: Yes. The medicine is safe to be consumed by lactating mothers. However, it is highly recommended that patients should administer medicine only if prescribed by a doctor.

16) What are the storage requirements for medicine?

Ans:

  • The medicine should be stored away from direct sunlight and heat.
  • It should be stored in a dry and cool place.
  • The medicine should be kept out of reach of pets and children

17) Is Lonazep banned in India?

Ans: Lonazep is a prescription-only medicine that is available at all medical stores. It is not banned in India.

18) Is Lonazep a prescription-only drug?

Ans: Yes, Lonazep is a prescription-only drug which is used for the treatment of epilepsy and seizures.  The medicine belongs to a category of schedule H drugs; it cannot be purchased without a prescription from a doctor.

19) Do I need to avoid a particular food item while administering a dose of Lonazep Tablet?

Ans: No, you do not need to avoid a particular food item while administering a dose of Lonazep tablet. The medicine is not known to cause any interaction with the food items. However, your doctor may ask you to avoid certain products depending upon your condition.

20) What are the general precautions and warnings to be followed while taking Lonazep Tablet?

Ans:

  • The patients are advised to inform their doctor about any ongoing medicines and treatments.
  • Patients suffering from liver and kidney related ailments must consume medicine only on the advice of a doctor.
  • Patients must avoid driving immediately after the consumption of Lonazep tablets.
  • Pregnant women must administer this medicine only if deemed absolutely necessary by a doctor.
  • The medicine should not be administered by patients suffering from genetic disorders such as galactose intolerance and Lapp lactase deficiency.
  • Patients consuming other central nervous system depressants drugs must not consume this medicine.
  • Lactating mothers are advised not to consume this medicine as it may pass from the milk and harm the baby.
  • Patients sensitive to the ingredients of the medicine must not consume it.
  • Patients suffering from long-term pulmonary insufficiency are at increased risk of suffering from adverse side effects on consuming this medicine. Extra caution must be practised in such patients.
  • Patients suffering from porphyria must not consume this medicine as it increases the risk of convulsions in such patients.

21) What if I miss a single dose of Lonazep?

Ans: It is generally advised to take the missed dose as soon as possible. If it is almost time for the next scheduled dose, it is recommended to administer the next dose and not take the skipped dose. Under no circumstance should a double dose be taken to compensate for the missed dose as it may lead to drug toxicity or other side effects.

Read More: Nicip Plus | Pan D | Meftal P

Last updated on : 09-05-2019

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