Methycobal 500 MCG Tablet: Uses, Side Effects, Price & Dosages

Methycobal belongs to the category of pure form of Vitamin B12. The medicine is prescribed for the treatment of vitamin B12 deficiency and pernicious anemia. The medicine is manufactured by Wockhardt limited. Although, it is an over the counter medicine, it is advised to consume the medicine after consulting a medical practitioner. This eliminates the risk of possible interactions and side effects. The medicine contains Methylcobalamin as its main ingredient. It contributes in regulating certain vital functions such as protein synthesis, cell multiplication and blood formation. It is also used in the treatment of Vitamin B12 deficiency.

Nature Vitamin B-12 supplement
Composition Mecobalamin
Uses Low hemoglobin, Loss of consciousness
Side effects Nausea, vomiting, diarrhea
Precautions It should be avoided by patients with liver impairments.

Uses and Benefits of Methycobal:

Methycobal is used in the prevention and treatment of following conditions and symptoms:

  • Peripheral Neuropathy: It is defined as a condition where the nerves responsible for carrying messages from brain and spinal cords to the rest of the body get damaged. The damage results in pain and numbness in hands and legs.
  • Megaloblastic Anemia: It is a condition where the bone marrow produces abnormally structured, large and immature red blood cells; also referred to as Megaloblasts. It is advised in the treatment of Megaloblastic anemia as well as in the prevention of Pernicious anemia. It is a type of Megaloblastic anemia where the body is unable to absorb Vitamin B12 from the gastrointestinal tract.
  • Diabetic neuropathy: It is a type of nerve damage caused due to diabetes. It is advised for the treatment of Diabetic Neuropathy.
  • Arthritis: Methycobal acts as adjuvant in the treatment of Arthritis and specifically Rheumatoid arthritis.
  • Sclerosis: Sclerosis is a condition where the immune system damages the covering of nerves. It is used in the treatment of lateral sclerosis.

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Side Effects of Methycobal:

Apart from the desired effect, consumption of Methycobal may result in some undesired effects as well. These undesired effects vary from person to person depending on the clinical condition and ongoing medications.

  • Abdominal pain
  • Nausea and vomiting
  • Vaginal bleeding
  • Skin rash
  • Redness of skin
  • Vaginal infection
  • A headache
  • Loss of appetite
  • Diarrhea
  • Dizziness
  • Decreased appetite
  • Chest pain and discomfort

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Common Dosage of Methycobal:

The dose of Methycobal is recommend on the basis of several factors such as medical condition, severity of the condition, age, allergic history and response of the body to the first dose. Usually, the suggested dose for adult is 3 tablets a day which is 1500 mcg of Vitamin B12. If it is administered in intravenous way then the usual dose is 500 mcg thrice a week.An individual should strictly adhere to the suggested dosage. Any dose alteration should only be done only after consulting a medical practitioner. In case of a missed dose, the medicine should be taken as soon as one remembers. If it is already time for the next dose, then the usual dose should be continued instead of overdosing to compensate for the missed dose. If an individual overdoses on Methycobal, one should seek medical attention without any delay; as overdose of Methycobal may result in severe symptoms. Use of Methycobal is not recommended for paediatric use. Hence, it is advised to consult a pediatrician before providing the medicine to children.

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Composition & Nature of Methycobal:

The drug constitutes of methylcobalamin which belongs to a class of organic compounds known as cobalamin derivatives. A cobalamin is actually a form of Vitamin B12 with a methyl group. It assists in the production of the RBCs and is often effective as a dietary supplement in the treatment of anaemia.

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Warnings/Precautions- When to avoid Methycobal 500 MCG Tablet?

Following points must be kept in mind while taking Methycobal 500 MCG Tablet –

  • Pregnant women should avoid the use of medicine after first trimester unless asked by a medical practitioner.
  • The medicine is found to be safe for use by breastfeeding women. However, a medical practitioner should be consulted in advance to avoid any risk of side effects.
  • The medicine may affect liver; hence, dosage adjustment may be required.
  • Patients with a history of allergy to Methycobal or its ingredient should avoid inform the medical practitioner beforehand.
  • An individual with recent history of gastrointestinal surgery should avoid the use of Methycobal.
  • People coming in contact with Mercury should practice caution while using Methycobal.
  • Elderly people may not have capacity to absorb the Methycobal through intestines. In such case appropriate dose adjustment and clinical monitoring is recommended.

Substitutes for Methycobal:

There are other medicines with same ingredients and strength as that of Methycobal. Here is a list of substitutes:

  • Elmecob 500 MCG Tablet by Torrent Pharmaceuticals Ltd
  • Mecoba 500 MCG Tablet by Abbott Healthcare Pvt. Ltd
  • Biocobal 500 MCG Tablet by Orchid Chemicals & Pharmaceuticals Ltd
  • Becotin Capsule manufactured by French Care Formulations
  • Nurokind 500 MCG Tablet by Mankind Pharmaceuticals Ltd
  • Cobamet 500 MCG Tablet by Sun Pharma Laboratories Ltd
  • Cadmin Tablet manufactured by Cadmus
  • Mecofol Tablet manufactured by Intas Pharmaceuticals Ltd

Methycobal Interactions:

Methycobal when consumed along with certain medicines or in case of certain medical condition, it may result in interaction. The interaction may lead to undesired effects.

Here is list of possible interactions:

Drug interactions

Two drugs when taken together may result in drug interaction. The interaction may lead to neutralization of effect of either of the medicines or an undesirable effect.

Here is a possible list of possible interactions:

  • Antacids: Consuming Antacids along with Methycobal may interfere with its absorption. Hence, it is advised to ask for an appropriate dose adjustment or a suitable alternative from a medical practitioner.
  • Folic acid: Supplements of Folic acid can mask the symptoms of anemia caused due to vitamin B12 deficiency. Hence, it is advised to consult the medical practitioner to ensure the correct supplement is being consumed.
  • Antibiotics: Use of antibiotics along with Methycobal reduces the absorption and induces reversible mal-absorption of Methycobal.

Hence, it is advised to inform the medical practitioner about the use of antibiotics beforehand.

To avoid any risk of drug interaction, it is advised to inform the medical practitioner about the ongoing medication (herbal medicine, vitamin supplements, etc.) beforehand.

Interaction with alcohol

Consumption of alcohol along with Methycobal can interfere with the absorption of the medicine. This can result in undesired effects.

Hence, it is not advised to consume alcohol along with Methycobal.

Interaction with Diseases

Methycobal when consumed in case of certain medical conditions can result in worsening of the present medical condition or severe side effects.

Hence, it is advised to inform the medical practitioner about any medical condition.

Methycobal can interact with the following disease:

  • Leber’s disease: It is a rare genetic disorder and use of Methycobal should be prohibited in this condition.

It is advised to inform the doctor in advance about this medical condition.

Methycobal Variants:

It is also available in the following variants:

Medicine variants Composition
Methycobal D Tablet Alpha Lipoic Acid 100mg + Folic Acid 1.5mg + Mecobalamin 1500mcg + Pyridoxine 3mg + Vitamin D3 1000 IU
Methycobal Injection Mecobalamin 500mcg/injection

Medicines that should not be taken with Methycobal 500 MCG Tablet:

It should not be combined along with following medicines:

  • Famotidine
  • Lansoprazole
  • Neomycin
  • Omeprazole
  • Colchicine
  • Ranitidine
  • Chloramphenicol
  • Cimetidine
  • Ranitidine

How to Store Methycobal?

  • Keep Methycobal at room temperature
  • Do not keep the medicine under direct heat or sunlight.
  • Do not freeze Methycobal unless mentioned on the package insert.
  • Keep it away from the reach of pets and children.
  • Do not flush Methycobal down the toilet or pour it into the sink for disposal.

Methycobal Price in India

Medicine Price
Methycobal Tablet INR 113

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How to use Methycobal?

  • It is available in the form of oral tablets as well as injections.
  • The tablet should be administered orally with water. The medicine can be taken with or without food. However, it should be taken with food by people suffering from gastric problems.
  • The oral tablets should not be chewed or broken before consumption. It should be swallowed whole.
  • The tablet should be administered immediately after opening the package, as the medicine is light sensitive.
  • Methycobal tablet should be consumed at an equal interval of time for best results.
  • If it is administered intravenously, then the medicine should be injected immediately after taking it out form the vial as the medicine is sensitive to the light.
  • Also, it is advised to not inject the medicine at the same site repeatedly.
  • If the medicine is taken as an over the counter medicine, then the leaflet should be read properly to get a proper idea of the medicine. This will also help in avoiding probable side effects and interactions.

How does Methycobal work?

It contains Mecobalamin as its main ingredient. It is a type of Vitamin B12. Mecobalamin plays a vital role in the production and maturation of red blood cells. Methycobal acts as a coenzyme and aids in the conversion of homocysteine to methionine; as excess of homocysteine can result in swelling of blood vessels. The ingredient of the medicine facilitates protein synthesis and protects the nerve cells.

Methycobal Storage:

  • The medicine should be stored at room temperature.
  • It should not be exposed to direct heat and light.
  • Exposing the medicine to direct sunlight will degenerate the medicine resulting in the change of color of the medicine.
  • The place of storage should not be at the reach of children and pets.
  • The medicine should be stored in airtight container.
  • It should not be flushed off or poured in the drain. Doing so may contaminate the environment.

When is Methycobal 500 MCG tablet prescribed?

Ans: Methycobal 500 MCG Tablet is composed of Methylcobalamin which is naturally occurring and a pure form of Vitamin B12.  The medicine is usually prescribed for the treatment of Vitamin B12 deficiency, alcoholic neuropathy, diabetic neuropathy, lateral sclerosis, etc. Methycobal works by regulating activities such as cell multiplication, protein synthesis, blood construction etc.

it is prescribed in the following conditions:

  • Pain in extremities
  • Low hemoglobin
  • Loss of sensation
  • Lateral Sclerosis
  • Deficiency of Vitamin B12 and folic acid
  • Numbness and pain in hands and feet due to nerve damage
  • Loss of consciousness
  • Adjunct therapy in severe muscle tightness
  • Decrease in the muscle mass


1) What is the use of Methycobal?

Ans: The medicine is used as a dietary supplement in case of deficiency of vitamin B12. It plays an important role in fulfilling the deficiency of vitamin B12.  The medicine also aids in the treatment of certain medical conditions such as anemia. It also helps determine vitamin B12 absorption in the Schilling test.

2) What is the natural source of Vitamin B12?

Ans: Vitamin B12 is an essential vitamin present in food items that we consumed on daily basis- meat, dairy products and eggs.

3) What are the side effects of using Methycobal 500 MCG Tablet?

Ans: Some of the side effects associated with the use of Methycobal 500 MCG Tablet are abdominal pain, skin rashes, a headache, redness of the skin, vaginal infection, nausea and vomiting etc.

4) What could be the possible contraindications of taking Methycobal Tablet?

Ans: The medicine should not be consumed by people suffering from Leber’s disease. Other than that the medicine should be avoided by people who have a history of allergy with the medicine or its ingredient.

5). Can Methycobal be administered in pain extremities and adjunct therapy in severe muscle tightness?

Ans: Yes, Methycobal Tablet can be administered to treat pain in adjunct therapy and muscle tightness. However, the doctor must be consulted before taking the medicine

6) What is the function of Methylcobalamin?

Ans: Methylcobalamin is a naturally occurring form of vitamin B12.  This vitamin is crucial for the normal functioning of the brain and the nervous system.

7) How long does an individual need to administer Methycobal before they can see improvement in their condition?

Ans: The patient may experience improvement in the conditions as early as a day or within two weeks. However, medicine’s response may vary from patient to patient depending upon their condition.

8) Can a patient immediately stop using Methycobal or it has to be slowly weaned off?

Ans: To get the desired effect of the medicine, it is important that the medicines should be taken in a proper manner. A certain amount of medicine has to be always present in the body to show the effect. If a patient abruptly stops consuming Methycobal, the problems may not be eliminated completely and may reoccur.

In case a patient is facing any side-effects, it must be informed to the doctor. He/she may thereafter alter Methycobal dosage or ask the patient to stop its consumption. However, the medicine must not be stopped without a doctor’s advice.

9) What is the time required for onset of action of Methycobal?

Ans: The peak effect of Methycobal starts within 3 hours of the oral intake.

10) Should Methycobal be taken on an empty stomach or full stomach?

Ans: Methycobal 500 MCG Tablet is usually consumed after having a meal. However, the medicine should be consumed in the manner as advised by the doctor.

11) Is it habit forming?

Ans: No habit-forming tendencies have been reported.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

User Comments (1)


Muhammad Farooq

Wed Jun 19 2019

I am patient of type2 diabatic I will use methycobal 500 mg with Trivia 100 (sitagliptin)due to allergic iissue


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