Metrogyl 400 MG Tablet: Uses, Dosage & Side Effects

Metrogyl 400 MG Tablet

What is Metrogyl 400 Tablet?

Metrogyl tablet is used for the treatment of infections, which are caused by some types of bacteria and other organisms, of stomach, mouth, intestine sometimes lungs and other body parts. Metrogyl also helps in preventing the infections from spreading and relieving symptoms like pain, inflammation. Metrogyl contains Metronidazole as the main ingredient, and belongs to the class of nitroimidazoles.

  • Nature of Metrogyl tablet: Antiprotozoal and antibiotic drug
  • Uses of Metrogyl tablet: Bacterial Vaginosis, Amebiasis, Surgical Prophylaxis, bacterial Infections
  • Composition of Metrogyl tablet: Metronidazole
  • Side effects of Metrogyl tablet: Agitation, Skin Rash, Dizziness, Constipation, Convulsion
  • Precautions: Pregnancy, Lactation, Liver problem, Blood cell count

Metrogyl 400 mg Tablet comes under the class of antiprotozoal drugs. The function of these drugs is to treat infections in the stomach and genital areas. It is an antibacterial and antiprotozoal tablet which is used in treatment of bacterial and parasitic infections such as the brain infections, infections of reproductive system, infections of gastrointestinal tract, and skin infections. The main salt of the tablet is Metronidazole.

Metrogyl 400 MG Tablet Composition:

The main salt of Metrogyl 400 is Metronidazole which is an antibiotic drug. It works by killing bacteria and other microorganisms that can cause infections by damaging the DNA. It inhibits the production of the energy of the bacteria and the parasites.

Metrogyl 400 MG Tablet Uses& Benefits:

Primarily, Metrogyl 400 MG Tablet is used for treating infections in the body parts such as stomach and genital areas. The other uses are listed below:

1. Amebiasis

Amebiasis is a type of intestinal parasitic infection which is caused by the protozoan Entameoba hystolytica or E. hystolytica. Patients showing symptoms such as loose stool, abdominal cramping, and stomach pain are prescribed Metrogyl 400 MG Tablet.

2. Trichomoniasis

Trichomoniasis is one of the most common sexually transmitted disease (STD). It is also known as Trich. Trich is caused due to an infection by protozoan parasite called Trichomonas vaginalis. The common symptoms include itching and burning inside the genitals, discomfort after urination, and change in discharge from penis/vagina. Metrogyl 400 MG Tablet is prescribed to treat these symptoms.

3. Bacterial Vaginosis

It is mild infection of the vagina. It is caused due to an imbalance of bacterial flora in the vagina. It usually occurs when women have physical encounters with more than one sexual partner. Metrogyl 400 MG Tablet is prescribed if the patient is showing symptoms such as change in vaginal discharge, burning sensation during urination, and itching around the vagina.

4. Bacterial Infections

Bacterial infections are generally caused in blood, lungs, and genital areas. It is caused due to the presence of Bacteroides fragillis and Clostridium species. Metrogyl 400 MG Tablet is used to treat the symptoms of bacterial infections such as fever, chills, localised swelling, throat pain, and vomiting.

5. Surgical Prophylaxis

Metrogyl 400 MG Tablet is prescribed to treat the infections that are generally caused as an after effect of surgery. Metrogyl 400 MG Tablet treats the symptoms such as fever, swelling of the incision, redness, and pain.

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Metrogyl 400 MG Tablet Side Effect

For the best and intended results use the metrogyl as prescribed and advised by the doctor. There might be some side effects of the metrogyl 400 mg tablet but once the course is complete, they will subside. If the side effects are adverse, medical attention should be taken.

  • Change in Taste
  • Unpleasant reaction if taken with alcohol
  • Abdominal Pain
  • Dizziness
  • Dry Mouth
  • Agitation
  • Burning or tingling sensation
  • Convulsion
  • Fever and chills
  • Skin Rash
  • Vaginal Irritation
  • Loss of Appetite
  • Constipation
  • Yellow colored eyes or skin

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Metrogyl 400 MG Tablet Dosage:

The dose of Metrogyl 400 mg tablet depends on the condition and its severity. The duration of the course also depends on the type of illness a person is suffering from and the bodily condition. To avoid any complications, consult a doctor before consuming the medicine and discuss medical conditions, if any.

Metrogyl 400 MG Tablet Missed Dose

The Metrogyl 400 mg tablet should be taken as per the recommendation of the doctor. However, if a dose is missed it should be taken as soon as possible. If it is time for your next time, then the missed dose should be skipped. Doses should not be doubled just to make up for the missed dose.

Metrogyl 400 MG Tablet Overdose

If the Metrogyl 400 mg tablet is taken as per the duration and dosage recommended by the doctor, the chance of overdose is very low. However, if an overdose is suspected emergency medical attention should be practiced.

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How to Use Metrogyl 400 mg Tablet:

Metrogyl 400 mg tablet should be taken as per the recommendation of the doctor in the exact duration and dosage as directed. The whole tablet should be swallowed. The tablet of Metrogyl 400 MG should not be chewed, crushed, or bit. This medicine is intended to be consumed with food. Metrogyl 400 mg tablet should not be consumed with food items that are antiplatelet in nature such as alfalfa, anise, grape seed, garlic, green tea, turmeric, fenugreek, bilberry and ginger.

How Metrogyl 400 mg Tablet Works?

Metrogyl 400 MG Tablet comes under the class of antiprotozoal drugs and is used to treat infections caused by bacteria and parasites in the body. It works by inhibiting the production of energy in the body and killing the bacteria and parasites in the body that are responsible for the infection.

What Metrogyl 400 mg Tablet  is prescribed for?

The Metrogyl 400 MG Tablet is prescribed for following medical conditions:

  • Blood infections
  • Bone infections
  • Genital tract infections
  • Lungs infections
  • Stomach and GI tract infections
  • Leg sores
  • Ulcers
  • Mouth infections including tooth and gum infections

How to Store Metrogyl 400 mg Tablet ?

It is advised to store the Metrogyl 400 mg tablet at a temperature below 25 ºC. Also, the packaging and the medicine should be protected from moisture and direct sunlight. It should be kept away from the reach of children and pets.

Related Warnings/Precautions To Metrogyl 400 mg Tablet:

  • Pregnancy – Consuming Metrogyl 400 MG Tablet in the first trimester of pregnancy is not recommended to treat bacterial vaginosis and trichomoniasis. Metrogyl 400 MG Tablet can be used in the second and third trimester but only if needed and after the consultation of the doctor .
  • Breastfeeding – The consumption of tablet of Metrogyl 400 mg is not recommended in women who are breastfeeding. It has been reported to that this medicine leads to discharge in breast milk. It is necessary to monitor for candida infections and diarrhoea.
  • Blood Cell Count – This use of this medicine can lower the blood cell count which results in leukopenia, thrombocytopenia, and bone marrow aplasia. It is important to a keep a check on WBC count, and platelets. If low blood count is suspected, treatment should be discontinued.
  • Neurologic Toxicity – The use of Metrogyl 400 mg tablet might cause neurological effects such as convulsion and peripheral neuropathy. If any neurological problem arises, it should be reported to the doctor. Symptoms such as convulsion, tingling, and burning sensation should be reported to the doctor.
  • Impaired Liver Function – The tablet of Metrogyl 400 mg might result in liver injury. The baseline of liver enzymes should be obtained before initiating the treatment. Signs of elevation of liver enzymes should be reported to the doctor.

Metrogyl 400 mg Tablet Substitutes:

If Metrogyl 400 mg Tablet is not available, then alternative substitutes can be taken.

  1. Unimegyl
  2. Metro 400 mg
  3. Metropen 400 mg
  4. Metgyl 400 mg
  5. Aristogyl 400 mg
  6. Balgyl 400 mg
  7. Flagyl 400 mg
  8. Metron 400 mg
  9. Metronidazole 400 mg

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Metrogyl 400 mg Tablet Interactions:

Drugs interact differently for different person to person. Before starting Metrogyl 400 you should check the possible interactions with the doctor.

Metrogyl 400 mg Tablet Interaction with Alcohol

  • Consumption of alcohol during nitroimidazole therapy may result in disulfiram-like reaction. It is not advised to consume alcohol when taking Metrogyl 400 medicine as it may induce symptoms such as dizziness.

Metrogyl 400 mg Tablet Interaction with Medicine

There are certain medicines which should not be consumed when Metrogyl 400 mg is being consumed. Metrogyl 400 containing following drug as an ingredient should be avoided, as it may result into severe medical conditions.

Some of the drug which should be avoided is mentioned below:

  • Warfarin (Severe): Metrogyl 400 mg when consumed along with warfarin may increase the concentration of warfarin in the blood, thus increasing the risk of bleeding. History of any blood disorders should be discussed with a medical practitioner beforehand and Metrogyl 400 mg should be replaced with a suitable substitute. In case of any side effects such as headache, blood in stools, unusual bleeding, dizziness, etc. should be reported to a doctor without any delay.
  • Ethinyl Estradiol (Moderate): This ingredient is used in contraceptive pills. If this is taken along with Metrogyl 400 mg, then desired result might not be achieved. Hence, it is advisable to take the substitute of the Metrogyl 400 after consulting a doctor.
  • Atorvastatin (Moderate): When consumed along with Metrogyl 400 mg, risk of nerve damage increases. If any unusual effect such as burning sensation, tingling, numbness, etc. is experienced then a doctor should be consulted immediately. A suitable substitute should be consumed instead of Metrogyl 400 to avoid any complications.
  • Disulfiram (Moderate): Consuming Metrogyl along with disulfiram can increase the risk of psychotic symptoms including confusion. A doctor should be informed if Disulfiram is being consumed. In case any unusual effects such as altered coordination, behavioural change and imitations are experienced then a doctor should be consulted without any delay.

Metrogyl 400 mg Tablet Interaction with Lab

The metrogyl may interfere with following lab test.

  • SGOT (Serum glutamic oxaloacetic transaminase)
  • LDH (Lactate dehydrogenase test)
  • ALT (Alanine transaminase test)
  • SGPT (Serum glutamic-pyruvic transaminase)
  • Triglycerides
  • Glucose Hexokinase

Metrogyl 400 mg Tablet Price:

Variants : Metrogyl 400mg, Price : INR 12.76 per strip of 15 tablets

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Metrogyl 400 mg Tablet  FAQs Answered:

1) Is it safe to consume Metrogyl 400 mg tablet during pregnancy?

Ans: Metrogyl 400 mg Tablet should be consumed during pregnancy if extremely necessary and only after consulting the doctor.

2) Is it safe to consume Metrogyl 400 mg tablet during breastfeeding?

Ans: It is not recommended to consume Metrogyl 400 mg Tablet during breastfeeding. Please consult the doctor for risks and benefits.

3) Is Metrogyl 400 prescribed for stomach infections and infections of gum and cavities?

Ans: Yes, Metrogyl 400 mg Tablet is prescribed for infections of stomach, gum and cavities. However, one should consult the doctor before consuming Metrogyl 400 for stomach and gum related infections.

4) How long does it take to see improvements in the conditions after taking Metrogyl 400?

Ans: It has been reported that patients see improvement in their conditions on the same day or after 1 day. This might be different from patient to patient. The duration of the consumption of the Metrogyl 400 medicine should be consulted with the doctor.

5) What is the frequency at which Metrogyl 400 should be consumed?

Ans: Commonly Metrogyl 400 mg Tablet should be consumed twice or thrice a day, depending on the condition of the patient. Please follow the advice of the doctor regarding the consumption of  tablet of metrogyl 400 mg.

6) Can Metrogyl 400 be consumed empty stomach?

Ans: It is advised that Metrogyl 400 mg Tablet should be consumed after food. However, it might be different for different patients. Please consult the doctor regarding the same.

7) Is it safe to operate heavy machinery or drive a vehicle when consuming Metrogyl 400?

Ans: If you are experiencing drowsiness, dizziness, or headache as the side effect of consuming Metrogyl 400, then it is advised not to operate machinery or drive a vehicle. If the blood pressure gets lowered extensively, one should not drive a vehicle. It is also advised not to drink alcohol with  tablet of metrogyl 400 mg.

8) Is Metrogyl 400 mg tablet addictive in nature?

Ans: The nature of Metrogyl 400 mg Tablet has not been reported as addictive. Any medicine that is categorized as controlled substance is labelled as H or X in India. No such indications have been found.

9) Can the consumption of Metrogyl 400 be stopped suddenly?

Ans: Some medications have been found to have rebound effect when stopped suddenly. For recommendations specific to your body, health and other medications, please consult your doctor.

10) What are the side effects of Metrogyl 400 mg tablet?

Ans: Metrogyl 400 mg Side effects may vary from one person to another depending on the clinical condition of a person. Some of the commonly complained side effects of Metrogyl 400 mg Tablet include the following:

  • Fever
  • Chills
  • Abdominal pain
  • Genital irritation
  • Dizziness
  • Dry mouth
  • Loos of appetite
  • Constipation
  • Skin rash

To avoid any kind of side effects, discuss all the details with doctor about the ongoing drugs, medical condition and allergy to any of the chemical ingredients used in the  tablet of metrogyl 400 mg.

11) What is Metrogyl 400 mg Tablet used for?

Ans: The tablet of metrogyl 400 mg belongs to the class of antibiotics drugs and is prescribed for the bacterial and parasitic infections.The metrogyl 400 mg tablet is found to be effective in following medical conditions:

  • Blood infections
  • Brain infections
  • Infection in intestinal tract
  • Infection in genital tract
  • Lung infection
  • Infection in teeth, gum and mouth
  • Ulcers and leg sores

12) How Metrogyl 400 should be stored?

Ans: The tablet of metrogyl 400 mg   should be stored at a temperature below 25 ºC. Also, the packing should be protected from moisture and direct sunlight.

13) How long do I need to take Metrogyl 400 after seeing an improvement?

Ans: Metrogyl 400 is an antibiotic which helps in the treatment of infections. It should be taken for a period of 5 to 7 days. It can be prescribed for longer or shorter duration depending on the condition and its severity.

14) How often should I take Metrogyl 400?

Ans: The dosage of the Metrogyl 400 is prescribed on the basis of medical condition and its severity as well as age of the patient. The schedule prescribed by the doctor should be strictly followed as per the instructions given by a medical practitioner. In any case, the schedule should not be altered. Also, it is advised not to share Metrogyl with individuals suffering from similar conditions.

15) Is Metrogyl recommended for loose motions?

Ans: Metrogyl belongs to the group of antiprotozoal that helps in the treatment of several infections in the genital areas and stomach. Hence, it can be used for loose motions.

16) Are there any possible contraindications with the consumption of Metrogyl 400?

Ans: Yes, there is a risk of contraindication. An individual allergic to Metrogyl 400 or any of its ingredients should avoid the use of Metrogyl.

17) What is metronidazole?

Ans: Metronidazole is an antibiotic and antiprotozoal medicine available under the brand name of Flagyl. The antibiotic is used to treat stomach and intestine infections, bacterial vaginosis, endocarditis and pelvic inflammatory diseases etc. Metronidazole is also found to be effective in the treatment of amebiasis, giardiasis, dracunculiasis and trichomoniasis.

18) Is Metrogyl used for chest infections?

Ans: Metrogyl 400 is rarely used for chest infections. The medicine should be taken for chest infections strictly under the guidance of a doctor.

19) Is it safe to use Metrogyl 400 during the lactation period?

Answer: Yes, Metrogyl is safe to be used in the lactation period. However, it is advised to ask a doctor before using the same to avoid any risk to the infant being breastfed.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

User Comments (1)


Prithwish Mitra

Fri Apr 26 2019

Occasionally suffering from lose motions with cramps,can take metrogyl 400?at which doses for how many days? Do have any other medicine are taking now.female,age -17yrs


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