Nexpro RD 40 Capsule: Uses, Side Effects, Composition, Dosages & Price

Nexpro RD 40 capsule is a medicine used for treating heartburn, gastro-esophageal reflux, peptic ulcer, and infection from helicobacter pylori. It is a dopamine antagonist drug that controls nausea and vomiting for those suffering from various gastro-intestinal diseases.

Nature: Dopamine antagonists
Uses: Gastric ulcers, vomiting and GERD
Composition : Domperidone and Esomeprazole
Side effects: Headache, gas, eczema and breast tenderness
Precautions : Alcohol, pregnancy, driving, kidney& liver disorder
Nexpro RD 40 Capsule

Uses and Benefits of Nexpro RD 40:

Nexpro RD 40 belongs to the class of dopamine antagonists that helps in preventing, treating and controlling the following disease and symptoms:

  • Peptic ulcer
  • Treatment for intractable vomiting and nausea
  • Treatment for symptoms linked with diabetic or idiopathic gastroparesis
  • Gas
  • Gastroesophageal reflux disease
  • Gastric ulcer
  • Helicobacter pylori infection
  • Zollinger-Ellison syndrome

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Side Effects of Nexpro RD 40:

There are a few possible side effects of using this drug. The occurrence of these side effects varies from person to person. The following is the list of potential side effects that can occur from Nexpro RD 40 capsule.

  • Headache
  • Gas
  • Eczema
  • Breast tenderness
  • Akathisia
  • Somnolence
  • Diarrhea
  • Rash
  • Pruritus
  • Breast enlargement
  • Blurred vision
  • Chest pain
  • Dryness in the mouth
  • Edema
  • Dyspepsia

One should consult the doctor if they observe any of the following side effects.

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Common Dosage of Nexpro RD 40:

Take Nexpro RD 40 as per the duration and dosage prescribed by the doctor. Do not crush, break or chew it, this Capsule should be swallowed whole. It is usually taken at least 30 minutes before having a meal. In case if the patient skips a dosage, he or she should take the missed dose immediately. But if it is time for the next dose, then it is better to skip the missed dose. It is advised not to take an extra dosage to make up for the missed dose. One should ignore taking an extra dose as it will not improve the symptoms, rather it may cause poisoning or side effects. In case overdose is suspected, follow up with the doctor and seek medical help right away.

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Composition & Nature of Nexpro RD 40:

Nexpro RD 40 capsule is composed of two main active ingredients – Domperidone and Esomeprazole.

Related Warnings/Precautions: When to avoid Nexpro RD 40?

Some precautions which need to be taken during the intake of Nexpro RD 40 are described below:

When consumed with alcohol, it can cause acid reflux and acidity in the esophagus, leading to heartburn. This would diminish the effect of this drug and can intensify your underlying situation. It may make you feel depressed, dizzy, or sleepy, hence you must ignore driving post consumption It should be cautiously used by people suffering from kidney ailments. Your doctor may suggest some dose adjustment as a precautionary measure. Those suffering from moderate or severe liver disorders must abstain from taking this medicine.  keep away from operating heavy machinery Check with a doctor if you have hepatic impairment, malignancy, or community-acquired pneumonia Discontinue usage if you experience indication or symptoms related with cardiac arrhythmia Smoking, drinking alcohol, consuming steroids, seizure medications, and family lineage of osteoporosis enhances the risk of osteoporosis on consuming this capsule Breastfeeding It may enhance the risk of lupus It may augment the risk of osteoporosis Monitor for symptoms and indications of bleeding Women should inform the doctor about their pregnancy or if they are planning pregnancy.

Substitutes for Nexpro RD 40:

The following medicines can be used instead of this medicine. These contain the same active ingredients as that of Nexpro RD 40 in the same strength.

  • Sompraz D 40 Capsule by Sun Pharmaceutical Industries Ltd
  • Esoz D 40 Capsule by Glenmark Pharmaceuticals Ltd
  • Raciper D 40 Capsule SR by Sun Pharmaceutical Industries Ltd
  • Esofag-D Capsule SR by Micro Labs Ltd
  • Esogress-D Capsule by La Renon Healthcare Pvt Ltd
  • Lupisoz-D Capsule by Lupin Ltd
  • Esopra D Capsule by Fitwel Pharmaceuticals Private Limited
  • Somtax-DSR Capsule by Inolife Healthcare
  • Esomecid D SR Capsule by Stallion Laboratories Pvt Ltd
  • Esovom-DSR Capsule by Mars Aventis Lifecare
  • Somi DSR Capsule by Desun Pharmaceuticals
  • Aspra-DSR Capsule by Shinto Organics (P) Limited
  • Esma-DSR Capsule by Shinto Organics (P) Limited
  • Magpep-DSR 30mg/40mg Capsule by Chemo Healthcare Pvt Ltd
  • Genpro-DSR Capsule by Shinto Organics (P) Limited

Nexpro RD 40 Interactions with Other Drugs:

It might interact with below-discussed drugs:

  • Amiodarone
  • Antacids
  • Amprenavir
  • Atropine
  • Aprepitant
  • Citalopram
  • Diazepam
  • Clarithromycin
  • Clomipramine

Nexpro RD 40 Variants:

The following are the variants of Nexpro RD 40:

  • Nexpro RD 20 capsule SR
  • Nexpro RD 40

Nexpro RD 40 Capsule Price in India:

  • Nexpro RD 20 capsule SR 132.5 INR
  • Nexpro RD 40 89.2 INR

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How Nexpro RD 40 Capsule Works?

It contains domperidone (dopamine D2 receptor) and esomeprazole (proton pump inhibitor). Esomeprazole controls the release of stomach acid that prevents sensation of heartburn. Domperidone controls the neurotransmitter dopamine that inhibits vomiting by preventing the food from flowing back to the food pipe. This is how this drug gives relief to patients from symptoms associated with GERD, like heartburn and nausea.

How to use Nexpro RD 40 Capsule?

The usual dosage of Nexpro RD 40 is 10 mg that is taken at least 30 minutes before having a meal. Nexpro RD 40 dose of this medicine is 30mg. The dosage of this drug depends on the weight, health condition and other medicines the patient is taking. It should be taken in the amount as told by the doctor. Nexpro RD 40 should not be used for more than 2 weeks unless told by the doctor. Also one should not self-medicate without a doctor’s recommendation.

When Nexpro RD 40 Capsule is prescribed?

Gastroesophageal reflux disease: In this condition, the stomach acid or bile that irritates the stomach lining. It helps in treating the slow passage of food in the gastrointestinal tract.
Peptic ulcer: These are open sores that occur inside the stomach and upper portion of the small intestine. The most common symptom of this condition is stomach ache.
Gastric ulcer: The other type of peptic ulcer is occurs in the upper part of the intestine. Both types of ulcers can occur at the same time. As Nexpro RD 40 is an NSAID it helps in treating these diseases.
Nausea and vomiting: It helps in preventing nausea and vomiting caused due to digestive system disorder. It reduces the stimulation in the vomiting center of the brain that helps in reducing nausea. Gastric motility disorders: It helps in curing these disorders that prevent stomach emptying

Medicines that should not be taken with Nexpro RD 40:

Taking two medicines or over-the-counter products at the same time can alter the effect of Nexpro RD 40. This may increase the risk for side-effects or reduce the effectiveness of Nexpro RD 40. This drug may interact with the following medicines and products:

  • Amiodarone
  • Amprenavir
  • Antacids
  • Aprepitant
  • Atazanavir
  • Atropine
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Diazepam

In order to avoid drug interaction, patients should tell about what all medicines, vitamins and herbal supplements they are using.

How to store Nexpro RD 40 Capsule?

Every medicine has its own recommended storage requirement, therefore one should check with the pharmacist about storage specific instructions. Nexpro RD 40 capsule should be stored at room temperature 15-30°C, away from heat and light. Do not freeze Nexpro RD 40 unless it is mentioned in the packaging. For the safety of the children, Nexpro RD 40 should be kept out of their reach. The same caution should be maintained in terms of disposal and expiration of this drug. Do not flush this medicine in the toilet or dispose of in the garbage carelessly, as it may harm the environment.


1) Can Nexpro RD 40 be used to treat gastric ulcers and symptoms linked with idiopathic or diabetic gastroparesis?

Ans: Yes, It is most commonly used for treating idiopathic or diabetic gastroparesis. But you must consult your physician prior to use; do not self-medicate.

2) For how long can Nexpro RD 40 be taken for visible improvement?

Ans: It is usually reported that signs of improvement can be observed within a day. But it may vary from one person to another. You need to consider your doctor’s recommendations regarding the duration of this drug.

3) In what frequency can Nexpro RD 40 be taken?

Ans: It’s usually reported to be taken two times a day by most patients or once a day. But it is advised to adhere to your physician’s advice regarding the same.

4) Is Nexpro RD 40 addictive?

Ans: Most drugs don’t have the potential to fall under the addictive category. Moreover, the government classifies addictive medicines under the segment of controlled substances. For example, it falls under schedule X or H as per the Indian government and schedules II to V according to the US government. You need to read the label carefully to ensure that Nexpro RD 40 doesn’t belong to any such special classification.

5) Is it considered safe to operate a machine or drive after consuming Nexpro RD 40 Capsule?

Ans: In case you experience any symptoms of headache, dizziness, drowsiness, or hypotension, it’s better to avoid using heavy machinery or driving on the road. Pharmacists recommend you not to consume alcohol along with medicines as it makes you even drowsier.

6) Does taking Nexpro RD 40 cause any side effects?

Ans: Yes, taking Nexpro RD 40 can result in the onset of serious side effects. Patients should seek immediate medical help.
The side effects of Nexpro RD 40 are:

  • Myalgia
  • Gynaecomastia (enlargement of the breast) in men
  • Blurred vision,
  • Reduction in white blood cells,
  • Depression ,
  • Alopaecia (loss of scalp hair).
  • Liver failure,
  • Fungal infections of the gastro-intestinal tract,
  • Kidney inflammation,
  • Hallucinations,
  • increased sweating
  • Gastric ulcer ,
  • Hernia

7) In what medical conditions Nexpro RD 40 should be avoided?

Ans: It should be avoided or used with caution in the following conditions:

  • Patients allergic to any of its components
  • Blockage in intestine
  • Patients with incorrect levels of magnesium, potassium and calcium
  • Severe kidney and liver disease
  • Cardiac arrest

8) How does this drug help in curing acidity?

Ans: It helps in curing acidity as it decreases stomach acid that causes acidity, burps, and uneasiness in the stomach. You can take this drug before having meal or as having told by the doctor.

9) For how long can I take Nexpro RD 40 Capsule?

Ans: Take this drug as told by the doctor. Do not take this drug for long term as it may cause side effects.

10) Does taking Nexpro RD 40 induces a dry mouth?

Ans: Yes, It causes dryness in the mouth. It is a common side effect of Nexpro RD 40 capusle. If you experience excessive dryness, keep yourself hydrated by drinking plenty of water, juice and shakes.

11) What happens in case of taking an expired dosage of Nexpro RD 40 Capsule?

Ans: Taking an expired dosage of Nexpro RD 40 will not cause any harm. But, you should discuss the harmful side effects of this drug ? , as an expired dosage may be ineffective in treating the symptoms or the condition. If you are suffering from a chronic illness then you should get in touch with your doctor so that you can avail the fresh supply of the unexpired medicines.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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