Ondem MD 4 contains ondansetron which is an anti-emetic used widely to treat nausea and vomiting associated with various disorders, disease conditions and surgical procedures. It is listed as one of the most effective and safe medicines in the World Health Organisation’s list of Essential Medicines.
Each tablet of Ondem MD 4 contains 4mg of Ondansetron which is the active ingredient. The tablet is available in different physical forms such as a disintegrating tablet, solution, film and tablet. Ondem MD 4 tablet exerts its peak pharmacologic action within 2 hours of ingestion and the anti-emetic effects may last between 12 to 24 hours depending on the condition of the individual patient and his/her underlying disorder.
Ondem MD 4 is used extensively to treat nausea and vomiting in the following scenarios:
Ondem MD 4 is well tolerated and side effects if any, are rare, minor and manageable. These include:
Immediate medical intervention should be sought if the following adverse side effects are being encountered:
All the side-effects listed may not be inclusive and any untoward change in normal function or behavior should be immediately reported to the medical practitioner.
Ondem MD 4 should always be taken at the recommended dose only after prescription by a qualified physician. The dose prescribed varies from patient to patient depending on the severity of the symptoms, underlying disease condition and the general health of the individual. For children, the criteria further include the age and weight of the child too. The dose prescribed is in the best interests of the patient and should neither be increased or stopped abruptly without consultation by a qualified physician.
Generally, in cases of chemotherapy, Ondem MD 4 is given half an hour before the start of therapy. In cases of radiotherapy, the drug is given at least 1-2 hours before the commencement of therapy. To prevent post-operative nausea and vomiting, Ondem MD 4 is given at least an hour before the start of surgery. For other indications, dosage recommended by the consulting physician should be followed.
It can be taken either alone or in combination with other anti-emetic medications. No dose adjustment is required in patients with kidney disorders or impaired kidney function tests.
Ondansetron, the active ingredient in Ondem MD 4 is a highly selective and specific 5-HT3 serotonin receptor antagonist. It has a low affinity towards dopamine receptors. The 5-HT3 receptors are present in the central nervous system in area postrema, a chemoreceptor trigger zone which acts as the vomiting center. They are also present at the vagal nerve terminals in the peripheral nervous system. The vomiting reflex is induced by serotonin from the intestinal cells in response to emetic factors such as chemotherapeutic agents. Ondem MD 4 acts predominantly by blocking receptors at the vagal nerve ends and to a smaller extent by blocking receptors in the central nervous system too.
Ondem MD 4 is not advised for use in children less than 5 years of age or elderly patients more than 75 years of age. Patients with impaired liver function tests should have dose adjustments after consultation with a registered medical practitioner.
Some common interactions of Ondem MD 4 with other medicines or substances:
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