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Ornidazole: Uses, Side Effects, Composition, Dosage & Price

Ornidazole is used to treat protozoan infections, bacterial infections, infections that may be caused during surgery and other conditions. Ornidazole works by inhibiting the production of microorganisms. It is also used to treat infections of the stomach, intestine and urinary tract.

 

Nature                        Antibiotic
UsesBacterial infections, protozoan infections andGiardiasis
CompositionOrindazole
Side effectsAllergic skin reaction, nausea and vomiting
PrecautionsBreastfeeding, pregnancy and alcohol

 

Ornidazole is available in the form of a tablet and should be administered as prescribed by the doctor.

 

Uses and Benefits of Ornidazole:

Ornidazole works by killing the bacteria and parasites that cause infections in the body. 

Some of the common uses of Ornidazole include the following:

  • Amebiasis: Ornidazole is prescribed for the treatment of infections in the intestine that are caused by Entamoeba histoliya, which are strains of protozoa. Some of the common signs of amebiasis include cramps, loose stool, and stomach pain. The parasites may enter other internal organs as well and cause an abscess or other complications.
  • Amoebic dysentery: Ornidazole is prescribed for the treatment of severe diarrhea, cramps, stomach pain, swelling of intestine and tiredness. It is caused due to amoeba.
  • Anaerobic bacterial infections: Ornidazole is used to treat infections that are caused by anaerobic bacteria. This bacterium occurs naturally in organs like heart, liver, respiratory and bones.
  • Bacterial vaginosis: Ornidazole is prescribed for the treatment of the bacterial growth in the vagina and is characterized by foul smell and abnormal vaginal discharge.
  • Giardiasis: Ornidazole is prescribed for the treatment of the infections in the intestine that are caused by strains of Giardia lambia protozoa. It causes fatigue, foul-smelling stool, and diarrhea.
  • Surgical prophylaxis: Ornidazole prevents infections that may be caused due to surgical procedures.
  • Trichomoniasis: Ornidazole is prescribed for the treatment of sexually transmitted diseases that are caused by Trichomonas vaginalis. These symptoms are dominant in women including foul smelling and abnormal vaginal discharge.

 

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Side Effects of Ornidazole:

Some of the common side effects that one can experience after Ornidazole may include dizziness, nausea, numbness, headache, vomiting, and seizures.

Some of the side effects of consuming Ornidazole include:

  • Abnormal taste
  • Allergic skin reaction
  • Decreased level of thyroid hormones in neonates
  • Deep tissue toxicity
  • Dizziness
  • Headache
  • Increased level of thyroid hormones
  • Increased sodium level in the blood
  • Metabolic acidosis
  • Mucous membrane toxicity
  • Nausea
  • Renal impairment
  • Skin discoloration
  • Sleepiness
  • Superficial keratitis
  • Tingling or numbness in the fingers or toes
  • Tremors
  • Vertigo
  • Vomiting

If any of the side effects are experienced, then the patients must consult a doctor at the earliest.

 

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Ornidazole Dosage:

Commonly, two Ornidazole tablets are prescribed in a day. Patients must consult a doctor and follow the prescribed dosage.

  • Missed dose: If a dose is missed then one should take the dose as soon as one remembers about it. But, if it is time for the next scheduled dose, then the missed dose should be skipped. Under no circumstances should the patients take an extra dose of Ornidazole to make up for the missed dose.
  • Overdose: An overdose of ornidazole may result in serious side effects. It is advised that patients immediately consult a doctor if an overdose is suspected.

 

Composition and nature of Ornidazole:

Ornidazole is an antibiotic which works by restricting bacteria and parasites that cause infections in the body. The active ingredient in Ornidazole is Ornidazole.

 

How to use Ornidazole?

Ornidazole is available in the form of tablets. It should be consumed orally and should not be crushed, broken or chewed. It should be consumed with water or as prescribed by the doctor. It is advisable to take Ornidazole after having a meal.

 

How Ornidazole works?

Ornidazole is effective in inhibiting growth of microorganism. It kills the bacteria by entering into the cells through diffusion and damages the DNA through formation of reactive nitro radicals. It is important for an individual to stick to the prescribed dosage, as the reaction to the medicine differs from person to person. 

 

When Ornidazole is prescribed?

Ornidazole is used to treat certain conditions such as anaerobic bacterial infections, bacterial vaginosis, and amebiasis. It is also used to treat infections that occur after surgeries. Doctors prescribe Ornidazole in the following conditions: 

  • Surgical prophylaxis: Ornidazole is used to prevent the chances of infections that can be caused after a surgical procedure.
  • Bacterial infection: Ornidazole is an effective medicine to treat infections caused by certain strains of anaerobic bacteria. This medicine is also used to treat infections caused by anaerobic bacteria in organs such as liver, heart, and respiratory tract.
  • Bacterial Vaginosis: Ornidazole helps in treating bacterial growth in the vaginal area. One may experience abnormal and foul smelling discharge.
  • Protozoan infections: These infections are caused by protozoa. These include organisms classified as amoebozoa, plasmodium and giardia lamblia. Ornidazole helps in treating protozoan infections.

 

Precautions and Warnings Related To Ornidazole:

Following are the various warnings and precautions related to the consumption of Ornidazole: 

  • Ornidazole is not recommended for individuals suffering from multiple sclerosis
  • Individuals suffering from epilepsy should not administer Ornidazole.
  • Patients should avoid taking Ornidazole if they are suffering from hepatic or renal impairment
  • This medicine must not be taken on an empty stomach.
  • Ornidazole must be swallowed along with water.
  • This medicine is not recommended for pregnant or breastfeeding women.

 

Substitutes of Ornidazole:

There are a number of substitutes available for Ornidazole which has the same composition and nature as that of Ornidazole. 

Some of the common substitutes of Ornidazole include:

  • Entamizole Plus 500 mg Tablet
  • Giro 500 mg Tablet
  • Orni 500 mg Tablet
  • Ornizen 500 mg Tablet
  • Ornizole 500 mg Tablet
  • Cucin O Tablet
  • Tocoderm Plus Cream
  • Orni O I.V. 200Mg/500Mg Infusion
  • Normet Suspension
  • O2 Tablet
  • Ornicef 200 Mg/500 Mg Tablet
  • Ornamac 200 Mg/500 Mg Tablet
  • Puradine Oz Ointment
  • Zifi O 200 Mg/500 Mg Tablet
  • Oflotas-Oz Tablet
  • Panderm V Gel
  • Norflox Oz Lb Tablet
  • Assault Novo 200 Mg/500 Mg Tablet
  • Oflavid Oz Tablet
  • Dermikem Oc Cream
  • Ornof Oz 200 Mg/500 Mg Tablet
  • Candifem Vaginal Cream
  • Woflox Oz 200 Mg/500 Mg Suspension
  • Triben Xt Cream
  • Ornof 200 Mg/500 Mg Infusion
  • Dto H 100 Mg/250 Mg
  • Ornigreat
  • Horn
  • Dazolic
  • Clorni
  • Ornigyl
  • Oniz
  • Ornimax
  • Azolic
  • Ramord

 

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Ornidazole Interactions:

A drug may interact with certain medicines, disease, food items and beverages. This interaction may result in adverse effects. Ornidazole interacts with the following:

Drug interaction

  • Vecuronium bromide
  • Warfarin

Interaction with alcohol

Ornidazole interacts with alcohol and may cause disulfiram reaction in certain individuals.

Disease interaction

Ornidazole interacts with diseases such as renal or hepatic impairment, allergic reactions and worsens the existing conditions. One must discuss their conditions before starting the course of the medication.

 

Medicines that should not be taken with Ornidazole

Taking two or more medicines may change the effect of the medicine or increase the risk of side-effects. Mentioned below are some of the medicines that should not be taken with Ornidazole:

  • Disulfiram
  • Warfarin and other oral anticoagulants
  • Lithium
  • Busulfan
  • Cimetidine
  • Phenytoin

Ornidazole should be stored at room temperature, away from heat and direct light. It is advised to keep this medicine away from the reach of children and pets.

 

Frequently Asked Question (FAQs):

 

1) Is it safe to consume Orindazole while breastfeeding?

Ans: No, the consumption of Ornidazole is not recommended while breastfeeding. It is advised to consult a doctor and understand the risks and benefits related to Ornidazole before starting the course of the medication. 

 

2) Can Orindazole be used to treat protozoan and bacterial infections?

Ans: Yes, Ornidazole can be used to treat protozoan and bacterial infections. However, one must consult a doctor before taking this medicine.

 

3) How long does it take to see improvements in the condition after taking Ornidazole?

Ans: On an average, it takes 1 to 3 days to see signs of improvements. However, if there are no signs of improvement then the patient must consult a doctor immediately. 

 

4) What is the frequency at which Ornidazole should be taken?

Ans: Usually, Ornidazole is prescribed to be taken not more than twice a day. Consult a doctor before taking this medicine and do not self-medicate.

 

5) Should Ornidazole be consumed on an empty stomach or after a meal?

Ans: Usually, Ornidazole is consumed after a meal. However, one must follow the directions given by the doctor.

 

6) Is it safe to operate heavy machinery or drive a vehicle after consuming Orindazole?

Ans: A commonly reported side effect of consuming Ornidazole is drowsiness. For this reason, it is recommended that the patient does not operate heavy machinery or drive a vehicle after taking this medicine.

 

7) Is Ornidazole a habit forming drug?

Ans: No, Ornidazole is not addictive or habit forming in nature. Make sure to check the package before buying the medicine. Also, consult a doctor before administering this medicine.

 

8) I forgot to take a dose of Orindazole. What should I do?

Ans: In case you have missed a dose of Orindazole, then you should take the missed dose immediately and if required skip the next dose. Ensure that you do not take an overdose. If in doubt, consult a doctor at the earliest.

 

9) I consumed an expired Orindazole tablet. What should I do?

Ans: In case you have consumed expired medicine it may not cause much trouble. However, to be on the safer side, consult a doctor at the earliest.

 

10) Can Orindazole provide relief from an upset stomach?

Ans: Yes, Orindazole can provide relief from an upset stomach that is caused by bacterial infection. However, consult a doctor who will create a proper course of treatment for you.

 

11) What is the function of Ornidazole?

Ans: Ornidazole is an antibiotic that works by restricting the production of bacteria and parasites and damages the DNA. It helps in treating infections of the brain, lung, bones and intestines. 

 

12) Under what conditions should the use of Ornidazole be avoided?

Ans: It is recommended to use Ornidazole in the following cases:

  • Renal/Hepatic impairment: Ornidazole should not be used by patients who are suffering from kidney or liver impairment. The use of Orindazole is not recommended if the impairment is severe.
  • Epilepsy: It is advised to use ornidazole with caution by patients who are suffering from epilepsy or other convulsion disorder.
  • Multiple sclerosis: Ornidazole should be used in caution by patients suffering from a neurodegenerative disorder of the brain.
  • Drowsiness: The use of Orindazole is associated with drowsiness in some patients. It is advised to refrain yourself from driving or operating heavy machinery in the early days of the treatment while you are on this medicine.
  • Hypothyroidism: It is advised not to use Ornidazole if you have a history of blood disease, hypothyroidism or hypoadrenalism.
  • Allergic reaction: Avoid taking this medicine if you are allergic to its ingredients present in the medicine.

 

13) Is it safe to use ornidazole for the treatment of loose motions?

Ans: Yes, ornidazole can be used for the treatment loose motions. Since, it is a prescription medicine hence you are advised to consult a doctor before taking this medicine.

 

14) What precautions should be taken while administering Ornidazole?

Ans: One should take the following precautions while administering Orindazole:

  • Ornidazole may not be effective in treating viral infections. Hence, unnecessary use of antibiotic should be avoided because it decreases its efficacy.
  • Avoid taking Ornidazole if you are allergic to metronidazole or nitroimidazoles.
  • Refrain from using Ornidazole if you are suffering from active neurological disorders.
  • Ornidazole must be used with caution in patients with diseases of the central nervous system such as epilepsy or multiple sclerosis.
  • Ornidazole can potentiate the symptoms of known or previously unrecognized candidiasis. Therefore, treatment with an antifungal agent may be required.
  • Ornidazole may interfere with certain laboratory tests, such as serum AST, ALT, SGOT, triglycerides, and glucose hexokinase.
  • It is advised to not to drive or operate heavy machinery after taking Ornidazole.

 

15) Is Ornidazole a steroid or an antibiotic?

Ans: Ornidazole is not a sulfa drug or steroid. It is an antibiotic that belongs to the class of medications known as nitroimidazole. It is used for treating conditions such as giardia, entamoeba and trichomonas. 

 

16) Can Ornidazole cause constipation?

Ans: No, Ornidazole does not constipation. But, if you are experiencing constipation, it advised to seek immediate medical help. 

 

17) Does administering Ornidazole causes allergy?

Ans: Yes, administration of Ornidazole may cause allergy. It is a rare but possible side effect of this medicine. One may feel shortness of breath, rashes or itching in the various different parts of the body. If you experience any such symptoms, it is advised to consult a doctor on priority. 

 

18) Can I stop taking Ornidazole once I see an improvement in my condition?

Ans: No, it is not advised to stop taking Ornidazole after seeing improvement in your conditions. It is advised to complete the full course of the medicine even if you feel better. There are chances that your symptom may improve before the infection is cured. 

 

19) Is it harmful to consume alcohol while consuming Ornidazole?

Ans: Alcohol consumption should be avoided while consuming Ornidazole for at least 3 days after completing the course of the medication. Drinking alcohol with Orindazole may cause nausea, stomach ache and redness of the face.

 

20) What are the possible side effects of administering Ornidazole?

Ans: Apart from its intended effect, Ornidazole may cause some undesirable side effects. In this case, one must seek immediate medical attention.

Mentioned below is the list of possible side effects caused by Ornidazole:

  • Skin discolouration
  • Renal impairment
  • Metabolic acidosis
  • Deep tissue toxicity
  • Mucous membrane toxicity
  • Keratitis
  • Fatigue
  • Dizziness
  • Breathing problem
  • Fever
  • Red spots on the skin
  • Tremors
  • Insomnia

 

21) What special dietary instructions should I follow?

Ans: Make sure you drink plenty of water while taking Ornidazole. The following food items should be avoided during the course of the medication: 

  • Alfalfa
  • Anise
  • Bilberry
  • Grapeseed
  • Green tea
  • Turmeric
  • Fenugreek
  • Garlic
  • Ginger

 

22) What should I know regarding the storage and disposal of Ornidazole?

Ans: Ornidazole should be stored at room temperature, away from heat and light. It should be kept away from the reach of children and pets. 

It is advised not to flush this medicine or discard them into drainage unless   instructed to do so. Please consult your pharmacist for more information as to how to safely discard Ornidazole. 

 

23) What is Ornidazole used to treat?

Ans: Ornidazole is an antibiotic that is used to treat the following conditions:

  • Blood infections
  • Infectious diseases of the genital tract, pelvic area, stomach and intestines
  • Infectious diseases of mouth, teeth, and gums
  • Prevent infections after surgery

 

24) Is Ornidazole safe for pregnant women?

Ans: The use of ornidazole is not recommended for pregnant women. It is advised to consult a gynecologist or an experienced doctor before starting the course of the medication. 

 

25) What is the onset action of Ornidazole?

Ans: The effect of this medicine lasts for at least 24 hours. 

 

26) Does Ornidazole have any adverse effect on organs?

Ans: If a patient is suffering from a liver or kidney disease this medicine may showcase altered effects and therefore must be used after consulting a doctor. Ornidazole may disturb the functioning of the kidney or liver in people suffering from such conditions.

 

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Last updated on : 27-02-2019

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