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Pacitane Tablet: Uses, Side Effects, Composition & Dosages

Pacitane belongs to a category of anticholinergic drugs that relax the muscles by slowing down the nerve impulses. The medicine is usually prescribed for the treatment of Parkinson's disease and extrapyramidal symptoms caused by the consumption of other medicines. Pacitan is manufactured by Pfizer Ltd.

Nature: Anticholinergic
Composition: Trihexyphenidyl (2mg)
Uses: Parkinson's disease, drug-induced abnormal movements
Side-effects: Dryness in mouth, nausea, vomiting, constipation, blurred vision
Precautions: High blood pressure, heart-related ailments, kidney or liver disorders, obstructive disease of digestive, genital and urinary tracts, glaucoma
Pacitane Tablet

Uses of Pacitane tablet:

Pacitane tablets are used for treating, containing, prevention and improvement of the following medical conditions and symptoms.

  • Movement disorder
  • Nervous system breakdown
  • Involuntary movement of face and jaw
  • Severe pain in nerves

These tablets can also be used for other purposes other than those listed above. Please consult a doctor before you take any drugs.

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Side Effects of Pacitane tablet:

Pacitane tablets may have some side effects on some users. These side effects are due to ingredients in the tablet. The list below is a partial list. While some side effects may be harmless others may be rare but serious. If is advisable to consult a doctor when you experience any side effects.

  • Blurring of vision
  • Anxiety
  • Constipation
  • Dizziness
  • Hallucination
  • Nervousness
  • Restlessness
  • Dryness of mouth
  • Dizziness
  • Glaucoma

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Dosage of Pacitane tablet:

The doctor may prescribe a dosage of Pacitane tablet depending upon the condition and age of the patient. A dose of three to four tablets may be prescribed to be taken in a day at regular intervals. The frequency and duration of the dose may be increased or decreased depending upon the condition of the patients.

  • Missed Dose : If a patient misses a dose of Pacitane tablets, it must be taken as soon as the patient remembers about it. However, if it is almost the time to consume the next dose, the previous dose must be skipped. Patients are advised not to consume two doses to compensate for the missed dose.
  • Overdose : Administering more than the prescribed dose of medicine may lead to severe side effects such as trouble in breathing, passing out etc. If an overdose is suspected, the patients must immediately visit a doctor.

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Composition and Nature of Pacitane tablet:

Pacitan is an anticholinergic drug which is composed of Trihexyphenidyl.

  • Trihexyphenidyl – It is an anticholinergic drug used in the symptomatic treatment of all etiologic groups of Parkinsonism and drug-induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of Parkinsonism.

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Pacitane Price in India:

Medicine Variant Manufacturer Price
Pacitane 2mg tablets Pfizer Ltd INR 38

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How to use Pacitane?

  • Pacitan must be taken orally after having a meal.
  • The tablets must not be broken, crushed or chewed prior to their consumption.
  • Pacitan must be consumed in dose and duration as prescribed by the doctor.

How Pacitane works?

Pacitane is composed of Trihexyphenidyl which is a selective antagonist for M1 muscarinic acetylcholine receptor. The compound is able to distinguish between the M1 (neuronal or cortical) and the peripheral muscarinic subtypes (glandular and cardiac). Trihexyphenidyl works by blocking the cholinergic activity of in the Central Nervous System which is responsible for the symptoms of Parkinson's disease.  This medicine is also thought to increase the availability of dopamine, a brain chemical that is vital for the initiation and control of voluntary muscle movements.

When Pacitane is prescribed?

Pacitan is usually prescribed for the treatment and prevention of Parkinson’s disease. It may also be prescribed to cure extrapyramidal symptoms which are caused due to the consumption of other medicines.

Precautions and Warnings - When to Avoid Pacitane tablet:

Following are the warnings and precautions that must be adhered to while administering Pacitane tablets –

  • The patients must inform the doctor about any ongoing medicines or treatments.
  • Patients allergic to Trihexyphenidyl are advised not to consume the medicine as it may cause severe allergic reactions.
  • Patients are advised to complete the course of medicine to completely eliminate the symptoms.
  • Patients having a history of convulsions or myocardial infraction must consult the doctor prior to starting the consumption of Pacitane tablets.
  • Patients consuming antidepressant medicines are advised to inform the doctor about their medication and practice extra caution while administering Pacitane tablets.
  • Patients suffering from conditions such as high blood pressure, liver-related ailments, kidney problems, glaucoma, myasthenia gravis etc. must exercise extra caution while administering this medicine.

Substitutes for Pacitane tablet:

Following are the substitutes of Pacitane tablets –

Parkin Tablet Micro Labs Ltd
Bexol Tablet Intas Pharmaceuticals Ltd
Hexylent Tablet Talent India
Tremnil 2mg Tablet Shine Pharmaceuticals Ltd
Triphen 2mg Tablet Sun Pharmaceutical Industries Ltd
Parkinta 2mg Tablet Arinna Lifescience Pvt. Ltd
Texy Tablet Triton Healthcare Pvt. Ltd
Dyskinil 2mg Tablet Crescent Therapeutics Ltd
Lahexy 2mg Tablet La Pharmaceuticals
Hexinal 2mg Tablet Torrent Pharmaceuticals Ltd
Barohexy Tablet Baroda Pharma Pvt. Ltd
Parales 2mg Tablet Psycormedies
Triden Tablet Ivy Healthcare
Ecitane 2mg Tablet Linux Laboratories
Nuhexy 2mg Tablet Nusearch Organic
Tri EX 2mg Tablet Tas Med India Pvt. Ltd
Trixyl 2mg Tablet A N Pharmacia

Pacitane tablet Interactions:

Interaction with medicine –

Pacitane may interact with the following medicines -

  • Esomeprazole
  • Lamotrigine
  • Pregabalin
  • Acetaminophen
  • Alprazolam
  • Aripiprazole
  • Aspirin
  • Carbamazepine
  • Cholecalciferol
  • Clonazepam
  • Duloxetine
  • Escitalopram
  • Quetiapine
  • Rasagiline
  • Risperidone
  • Topiramate
  • Ziprasidone

Interaction with diseases –

  • Gastrointestinal blockage : Patients suffering from gastrointestinal problems may experience severe side effects after the consumption of this medicine. The patients are advised to inform the doctor about their condition so that an alternative medicine can be prescribed.
  • Urinary tract obstruction : Pacitan is not recommended to patients suffering from urinary obstruction as it may lead to severe side effects. The patients are advised to inform the doctor about their condition so that an alternative medicine can be prescribed.

Interaction with alcohol –

Consuming Pacitane along with alcohol may induce excessive drowsiness and calmness in the patients. Therefore, patients are advised to avoid the consumption of alcohol while on Pacitane.

Pacitane Variants

A variant of Pacitane tablets is -

  • Pacitane 2mg tablets

Precautions and Warnings - When to Avoid Pacitane?

Following are the medicines that must not be consumed with Pacitane tablets –

  • Esomeprazole
  • Lamotrigine
  • Pregabalin
  • Acetaminophen
  • Alprazolam
  • Ziprasidone
  • Aripiprazole
  • Aspirin
  • Carbamazepine
  • Cholecalciferol
  • Duloxetine
  • Escitalopram
  • Quetiapine
  • Rasagiline
  • Risperidone
  • Topiramate
  • Clonazepam

How to store Pacitane?

  • Pacitan must be stored in a cool and dry place.
  • Pacitan must be kept away from the reach of children and pets.
  • Pacitan must be kept away from direct heat and sunlight.

FAQs

1) What will happen if I accidentally consume an expired dose of Pacitane Tablet?

Ans: Although it is always recommended to check the expiry date of Pacitan tablet before administering it, a single expired dose may not cause any severe side effects. It must be noted that the efficacy of Pacitan may be affected as an expired tablet will not be as effective in treating the symptoms. In case of experiencing any severe side effects, a doctor must be consulted immediately to seek remedial action.

2) Should I administer Pacitane Tablet before or after having a meal?

Ans: Pacitane should be consumed after having a meal. The patients are advised to follow the instructions given by the doctor on how to consume Pacitan tablet.

3) Does Pacitan have a habit-forming tendency?

Ans: No. Pacitan does have any habit-forming tendencies.

4) Is it safe to drive after consuming Pacitane tablets?

Ans: No, it is not safe to drive after the consumption of Pacitane tablets. The consumption of this medicine may cause side effects such as dizziness and blurred vision.

5) What will happen if I continuously forget to take Pacitane?

Ans: Missing a single dose of Pacitane tablet may not cause much effect. However, for a medicine to work properly some concentration of medicine should always be present in the body. If a patient continuously misses the dose of Pacitane, the medicine may not be able to completely cure the condition it has been prescribed for.

6) What will happen if overdose on Pacitane tablet?

Ans: Overdosing on Pacitane tablet may lead to severe side effects such as difficulty in breathing and being unconscious. If an overdose is suspected, patients must immediately visit a doctor.

7) What are the common side effects associated with Pacitane Tablet?

Ans: The common side effects associated with Pacitane Tablet are -

  • Blurring of vision
  • Anxiety
  • Constipation
  • Dizziness
  • Hallucination
  • Nervousness
  • Restlessness
  • Dryness of mouth
  • Dizziness
  • Glaucoma

8) Is Pacitane Tablet available as an Over- the- Counter medicine?

Ans: No, Pacitane is not an over-the-counter medicine. It can only be purchased after being prescribed by a doctor.

9) Can I take Pacitane Tablet along with other antidepressants?

Ans: No, antidepressants are not recommended to be administered along with Pacitane Tablets as they may interact and lead to severe side effects when co-administered. A doctor must be consulted for before starting the dose of any medicine to avoid the occurrence of drug interactions. .

10) What is Pacitane Tablet used for?

Ans: Pacitane tablets are used for treating, containing, prevention and improvement of the following medical conditions and symptoms.

  • Parkinson’s disease
  • Movement disorder
  • Nervous system breakdown
  • Severe pain in nerves
  • Involuntary movement of face and jaw

11) Can I immediately stop the consumption of this medicine as soon as I see improvement in my conditions?

Ans: No, it is not advisable to abruptly stop or alter the dosage of the medicine even if an improvement in the condition is experienced. Leaving the course of medicine in between may not completely cure the condition it has been prescribed for. The doctor must be consulted before stopping the consumption of the medicine as he may prescribe an alternate dose if side effects persist

12) Is Pacitane safe to be consumed by pregnant women?

Ans: No. The medicine is not safe to be consumed by pregnant women. This is because the medicine poses a serious threat to the health of a developing fetus. The medicine may be consumed by pregnant women only if the benefits outweigh the risks and the medicine is deemed absolutely necessary for consumption by the doctor.

13) Can Pacitane be prescribed to patients suffering from renal impairment?

Ans: No, the medicine cannot be administered to patients suffering from severe renal impairment. This is because the medicine may lead to severe side effects in such patients. Close monitoring of the functioning of the kidney and regular dosage alteration may be required in such patients.

14) Is Pacitane safe to be consumed by lactating mothers?

Ans: No, the medicine is not safe to be consumed by lactating mothers. Lactating mothers must not breastfeed the child until the medicine is completely eliminated from the body.

15) What are the storage requirements for medicine?

Ans:

  • The medicine should be stored away from direct sunlight and heat.
  • It should be stored in a dry and cool place.
  • The medicine should be kept out of reach of pets and children

16) Is Pacitane banned in India?

Ans: Pacitane is prescription only medicine which is readily available on all medical stores in India. The medicine can only be purchased after showing a prescription from the doctor.

17) Is Pacitane a prescription-only drug?

Ans: Yes, Pacitane is a prescription-only drug. The medicine is generally used for the treatment of Parkinson’s disease and extrapyramidal symptoms.  The medicine belongs to a category of anticholinergic drugs and cannot be purchased without a doctor’s prescription.

18) Do I need to avoid a particular food item while administering a dose of Pacitane Tablet?

Ans: No, the medicine does not interact with different food items. Therefore, there is no need to avoid a particular food item while administering Pacitane tablets.

19) What are the general precautions and warnings to be followed while taking Pacitane Tablet?

Ans: Following are the warnings and precautions that must be adhered to while administering Pacitane tablets –

  • The patients must inform the doctor about any ongoing medicines or treatments.
  • Patients allergic to Trihexyphenidyl are advised not to consume the medicine as it may cause severe allergic reactions.
  • Patients are advised to complete the course of medicine to completely eliminate the symptoms.
  • Patients having a history of convulsions or myocardial infraction must consult the doctor prior to starting the consumption of Pacitane tablets.
  • Patients consuming antidepressant medicines are advised to inform the doctor about their medication and practice extra caution while administering Pacitane tablets.
  • Patients suffering from conditions such as high blood pressure, liver-related ailments, kidney problems, glaucoma, myasthenia gravis etc. must exercise extra caution while administering this medicine.

20) What if I miss a single dose of Pacitane?

Ans: It is generally advised to take the missed dose as soon as possible. If it is almost time for the next scheduled dose, it is recommended to administer the next dose and not take the skipped dose. Under no circumstance should a double dose be taken to compensate for the missed dose as it may lead to drug toxicity or other side effects.

21) How much time does it take for Pacitane to show its effect?

Ans: The effect of Pacitane can be observed within one hour of administration of the dose.

22) What is the duration of effect of Pacitane tablets?

Ans: The effect of this medicine lasts for around 6-12 hours.

23) Can I consume Pacitane along with alcohol?

Ans: No, it is not advisable to consume Pacitane with alcohol as it may reduce the effect of the medicine.

24) Is Trihexyphenidyl used for the treatment of anxiety?

Ans: Anxiety is one of the side effects of consuming Pacitane tablets. Trihexyphenidyl is usually prescribed for the treatment of Parkinson’s disease and movement disorders induced by the consumption of other medicines.

25) Is Trihexyphenidyl a narcotic?

Ans: No, Trihexyphenidyl is not a narcotic. The medicine belongs to a class of anticholinergic drug used for the treatment of movement disorders induced by the consumption of other medicines and Parkinson’s disease.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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