Perinorm Tablet: Uses, Side Effects, Composition, Dosage & Price

Perinorm Tablet is an antiemetic drug categorized under dopamine-receptor antagonists group of medicines. It is used for the treatment of nausea and vomiting caused due to radiotherapy, migraine and chemotherapy. Other than this, Perinorm is also used for the treatment of gastritis, hiccups, stomach diseases, diabetes, and intestine related diseases.

Nature Antiemetic Drug
Composition Metoclopramide
Uses

Nausea, vomiting due to chemotherapy, radiotherapy

and migraine, lactation failure,gastritis, hiccups, heartburn

caused by Gastro-oesophageal Reflux Disease.

Side effects

Involuntary body movements, fatigue, diarrhea,

restlessness, slow heartbeats, increased prolactin

hormone level in men and women.

Precautions

Health conditions like dizziness, nervousness, and

headache, cirrhosis,congestive heart failure,

hypertension should be brought to the doctor’s notice.

Perinorm Tablet

Perinorm tablet is not recommended to be used in patients suffering from gastrointestinal disorders like gastrointestinal hemorrhage, mechanical obstruction, or gastrointestinal perforation. Perinorm tablet is a generic medicine and is manufactured in India by IPCA Laboratories Ltd.

Uses and Benifits of Perinorm:

Perinorm tablet is commonly prescribed to treat chemotherapy-related nausea and vomiting. However, it is also prescribed to treat, control, and prevent the following diseases and symptoms:

  • A migraine
  • Diabetic Gastroparesis
  • Lactation failure
  • Heartburn
  • Loss of appetite
  • Bloating
  • Hiccups
  • Stomach and intestine ulcers caused due to Gastro-oesophageal Reflux Diseases (GERD)

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Side Effects of Perinorm:

Perinorm medicines when consumed may result in occurrence of certain side effects. These side effects may or may not be life threatening and the occurrence of these side effects could be rare. In case effects other than the intended ones are experienced, must consult a doctor immediately. Some of the side effects of consuming Perinorm are:

Major side effects:

Mild to Moderate Side Effects:

  • Restlessness
  • Drowsiness
  • Headache
  • Sleep disturbances
  • Diarrhea
  • Parkinsonism
  • Increase in the prolactin hormone level.
  • Lack of Energy
  • Hallucinations
  • Hypotension
  • Hypersensitivity reactions
  • Changes in menstrual periods
  • Urinating more than usual
  • Breast tenderness or swelling
  • Diarrhea

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Common Dosage of Perinorm:

The dosage of Perinorm tablet is prescribed by the doctor after observing all aspects of the patient’s situation including their past history and current medications. Mostly, Perinorm is prescribed to be taken four times a day. Medicine is prescribed to be taken before each meal and one before sleeping at night.

  • Missed Dose : A missed dose of Perinorm tablet must be taken as soon as it is remembered. If the missed dose is remembered when it is almost time for the next dose, then the missed dose should be skipped. It is advisable to take the scheduled dose on time. One should not take an extra dose in order to make up for the missed dose.
  • Overdose : In case of an overdose, it is advised to seek immediate medical attention in order to avoid any adverse effects.

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Compositions and Nature of Perinorm:

There is only one active ingredient in the Perinorm tablet:

  • Metoclopramide (10 Mg) : The ingredient Metoclopramide is a prokinetic which works in the vomit centre of the brain. It also acts on the upper digestive tract to increase the movement of stomach and intestines, allowing food to move more easily through the stomach.

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Perinorm Tablet Prices in India:

Name of the Medicine Price
Perinorm Tablet (10 Tablets) INR12.15/-

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When is Perinorm Prescribed?

Perinorm tablet is an antiemetic which regulates the action of the brain for nausea and vomiting occurring as a result of chemotherapy, radiotherapy, and migraine. It is prescribed to relieve lactation failure, gastritis, hiccups, hiccoughs, and heartburn.

Perinorm also helps cure gastroparesis by increasing the gastric emptying which prevents bloating in the stomach and also plays a major role in curing gastro-oesophageal reflux disease as it increases the gastric emptying and reduces the gastric reflux.

How to use Perinorm?

The dose of Perinorm tablet is determined by the age, weight and medical condition of the patient. It is advisable to strictly follow the dose prescribed by the doctor.

  • The Perinorm should be swallowed whole without crushing, chewing or breaking.
  • It is advisable to take the Perinorm tablet on an empty stomach.
  • In case of mechanical bowel obstruction, bowel perforation, or gastrointestinal hemorrhage, the medicine should not be used.
  • During the administration of Perinorm, it is suggested to closely monitor the patient’s blood pressure, and symptoms like involuntary movements of the tongue, lips and the face.

How does Perinorm Work?

Perinorm basically perform two major functions:

  • Controls the sensations of vomiting, and
  • Helps emptying of the bowel

Perinorm tablet stimulates the release of a chemical messenger – acetylcholine. The release of this chemical messenger triggers the motility of the intestine. This medicine acts as a gastro-intestinal stimulant and works excellently when taken on an empty stomach as it inhibits the relaxation of the smooth muscles of the gastrointestinal tract.

Perinorm Tablet Related Warnings/Precautions:

Before administering Perinorm tablet, it is important to inform the doctor about any on-going medicines, over the counter products like vitamins, herbal supplements etc., allergic reactions to medicine ingredients, pre-existing diseases and existing health conditions like pregnancy, upcoming surgery etc.

Perinorm tablet is advised to be avoided in case the patient is suffering from:

  • Allergies
  • Seizures
  • Parkinson’s disease
  • High blood pressure
  • Epilepsy
  • Blockage of intestines
  • Breast cancer
  • Depression

There are certain warnings and precautions during the administration of Perinorm tablet which need to be observed with respect to the use of this medicine. It is important to remember the following points:

  • Allergy: The patient should stop taking the medicine in case any allergic reactions are observed.
  • Pregnancy and Breastfeeding: Perinorm tablet is safe to be used during pregnancy as animal studies of the medicine have shown low or no adverse effects on the foetus or the new born baby. Since human studies are limited in this regard, it is advisable to consult the doctor.
  • Driving and Operating Heavy Machinery: Perinorm tablet may cause drowsiness, dyskinesia, and dystonias which could affect the vision and may interfere with the ability to drive. Additionally, operating heavy machinery is also suggested to be avoided.
  • Uncontrollable Body Movements: Administration of Perinorm tablet may cause uncontrolled body movements like that of the tongue, eyes, legs, arms etc. In such cases, it is important to consult the doctor immediately.
  • Neuroleptic Malignant Syndrome (NMS): This condition is one of the well-known side-effects of taking this drug. This syndrome causes fever, altered consciousness and in some cases muscle rigidity. If any of these symptoms are observed, a doctor must be contacted immediately.
  • Kidney and Liver-Related Disorders: Perinorm tablet is advised to be used with caution among patients with kidney diseases. However, the medicine has been studied to be safe among patients with liver-related disorders. Limited data available suggests dose adjustment may be required as prescribed by the doctor based on the patient’s condition and response to the medicine.

Substitutes of Perinorm:

Certain substitutes for Perinorm tablet are listed as follows:

  • Reglan tablet manufactured by Adcock Ingram Healthcare Pvt. Ltd.
  • Emenorm tablet manufactured by Intas Pharmaceuticals Ltd.
  • Almet tablet manufactured by Alkem Laboratories Ltd.
  • Emenil tablet manufactured by Astra Zeneca
  • Maceron tablet manufactured by Wallace Pharmaceuticals Pvt. Ltd.
  • Reggi tablet manufactured by Menarini India Pvt. Ltd.
  • Promet tablet manufactured by Lupin Ltd.
  • Dysvon tablet manufactured by Suvik Hitek Pvt. Ltd.
  • Metotid tablet manufactured by Biological E Ltd.
  • Peripan tablet manufactured by Pan Pharmaceuticals Ltd.
  • Metvo tablet manufactured by APS Biotech Pvt. Ltd.
  • Actinorm tablet manufactured by Hinglaj Laboratories
  • Peronorm tablet manufactured by Klintoz Pharmaceuticals Pvt Ltd.
  • Motil tablet manufactured by TOSC international Pvt. Ltd.
  • Vomitrac tablet manufactured by Bindlysh Biotech Ltd.
  • Clomet tablet manufactured by Oyster Labs Ltd.
  • Gastrinorm tablet manufactured by Raymond Pharmaceutical Pvt. Ltd.
  • Vominorm tablet manufactured by Cipla Ltd.

Perinorm Interaction with Other Drugs:

Certain drug interactions may alter the effects of on-going medicines and can also increase the risk of any serious side effects. Perinorm should not be consumed with the following drugs:

Interaction with Drug

  • Pramipexole
  • Ropinirole
  • Piribedil
  • Cyclosporine
  • Fluvoxamine
  • Fluoxetine
  • Citalopram
  • Dapoxetine
  • Escitalopram
  • Sertraline
  • SERTA
  • Paropex
  • Estajoy
  • Osmoset
  • Cabergoline
  • Chlorothizaide
  • Benorylate
  • Aspirin
  • Atropine
  • Barium Sulphate
  • Biperiden
  • Chlorothiazide
  • Paroxetine
  • Paracetamol /Acetaminophen

Interaction with Diseases

Perinorm tablet is advised not to be taken in case of hypersensitivity. In addition, the medicine when taken with the following health conditions may cause a reaction and worsen the conditions.

  • Gastrointestinal Haemorrhage
  • Mechanical Obstruction and Perforation
  • Phaeochromocytoma
  • History of seizures
  • Abnormal movement of face and tongue
  • Aldosteronism
  • Bleeding of the stomach or intestines
  • Chronic heart failure
  • Deficiency of the blood enzyme cytochrome b5 reductase
  • Depression
  • Hardening of the liver
  • Having thoughts of suicide
  • Mechanical Intestinal Obstruction
  • Moderate to severe kidney impairment
  • Neuroleptic malignant syndrome
  • Parkinson symptoms
  • Porphyria
  • Rupture in the wall of the stomach or intestine
  • Surgical joining of two parts of the intestine
  • Tumor of adrenal gland causing high blood pressure
  • Water retention

Interaction with Alcohol

Consumption of alcohol during the course of treatment of Perinorm tablet is not advised as it leads to an additive effect which can affect the central nervous system, cause depression and/or impairment of judgment, thinking, and psychomotor skills.

Consumption of alcohol during the administration of Perinorm tablet can also increase the side effects like dizziness and lightheadedness. It is advisable to stop performing the activities that need high mental alertness like driving and operating heavy machinery.

Perinorm Variants and Suspension Forms

The following variants of Perinorm tablet are available:

  • Perinorm Injection (vial of 2 ml injection)
  • Perinorm Injection (vial of 20 ml injection)
  • Perinorm CD Capsule (strip of 10 capsules)
  • Perinorm Syrup (bottle of 60 ml syrup)
  • Perinorm 5mg Drops (pack of 30 ml drops)
  • Perinorm MPs 5 mg / 125 mg tablet (strip of 10 tablets)
  • Perinorm 10 mg tablet (strip of 10 tablets)

How to Store Perinorm?

The following storage tips should be followed in order to maintain the efficacy of Perinorm.

  • It is advised to store the medicine at room temperature away from direct sunlight and heat. The ideal temperature for storing Perinorm tablet is below 25 degrees Celsius.
  • Keep the medicine away from children and pets.

FAQs

1) Can Perinorm tablet be taken with Alcohol?

Ans: It is advised not to take Perinorm tablet with alcohol as it may cause excessive drowsiness.

2) Can Perinorm be taken during pregnancy?

Ans: Perinorm can be taken during pregnancy as there are no serious side effects observed. However, it is best to consult the doctor before administering the medicine.

3) Can Perinorm be taken during breastfeeding?

Ans: It is not advised to consume Perinorm tablet during breastfeeding as there have been serious side effects reported in lactating mothers as per medical studies.

4) Is it safe to administer Perinorm to patients with Kidney and Liver related ailments?

Ans: No, Perinorm tablet is not safe for consumption by patients suffering from kidney and liver related ailments. For patients with impaired renal function, Perinorm tablet may cause serious side effects. In case of liver patients, mild to moderate side effects may occur when Perinorm tablet is taken for a long duration. It is advised to consult the doctor before starting the treatment.

5) When are the effects of Perinorm tablet visible?

Ans: Perinorm tablet takes about 30 to 60 minutes to show the effects after being administered orally. In case an intravenous dose is administered, the effects are visible faster – after one to four minutes. In case one takes an intramuscular dose, the effects are visible after 10 to 15 minutes.

6) What should one do in case a dose of Perinorm is missed?

Ans: In case a dose of Perinorm tablet is missed, it is advisable to take the same as soon as possible. In case the dose is remembered when it is almost time for the next dose, the missed dose should be skipped and the next dose should be taken as scheduled.

7) Can Perinorm cause any effect on birth control pills?

Ans: No, Perinorm tablet does not interact with birth control pills and hence both medicines can be taken together, without any risks of side effects.

8) Does Perinorm tablet helps get rid of morning sickness?

Ans: Yes, Perinorm has been found to be helpful in getting rid of morning sickness. It is important to consult the doctor before administering the medicine, especially in the case pregnancy.

9) Can Perinorm be taken with antibiotics like Ibuprofen etc.?

Ans: Yes, Perinorm tablet can be taken with antibiotics such as Ibuprofen. Lab tests have not established any interactions between the two drugs but if any side effects or interactions are observed, one should immediately consult the doctor.

10) Is Perinorm an over the counter product?

Ans: No, Perinorm tablet is not an Over the Counter (OTC) medicine and a prescription is required from a registered doctor to ensure safe administration of the tablet.

11) Does Perinorm potentiate opioid?

Ans: Perinorm tablet potentiates only the sedative effects of opioids. This refers to sleep-inducing quality of the opioids which hampers the patient’s ability to drive and operate machinery. It is important to consult the doctor regarding the same.

12) Does Perinorm tablet cause constipation?

Ans: Perinorm tablet does not cause constipation and it is suggested to consult the doctor in case one experiences constipation. This may be due to other underlying conditions.

13) Can I use Perinorm while suffering from Parkinson’s disease?

Ans: No, Perinorm tablet is not advised in case one has a history of Parkinson’s disease.

14) What are the symptoms of an overdose of Perinorm?

Ans: When Perinorm tablet is taken in overdose, the following symptoms may occur:

  • Drowsiness
  • Confusion
  • Tremors
  • Convulsions

It is advisable to consult the doctor immediately in case these symptoms are experienced.

15) What is the mechanism of action of Perinorm tablet?

Ans: Perinorm tablet enhances the motility of the upper GI tract and increases the gastric emptying and does not affect the gastric, biliary or pancreatic secretion. It increases the duodenal peristalsis which decreases the transit time of food in the intestine.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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