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Regestrone Tablet: Uses, Side Effects, Composition & Dosages

Regestrone Tablet Prices and Dosage

Regestrone 5 MG Tablet is a progestin in a synthetic form and poses a similar function as that of the female hormone; progesterone. Doctors suggest the use of Regestrone in case of an imbalance of the hormones among women, disorders relating to the menstrual cycle, and during abnormal vaginal bleeding. This medicine is also prescribed as a birth control pill as it helps prevent unwanted pregnancy. It is effective for contraception of about 8 weeks.

Nature: Synthetic progestin hormone
Composition: Norethisterone
Uses: Heavy uterine bleeding, endometrial cancer, Amenorrhea
Side-effects: Swelling of lips, face, throat; stomach discomfort
Precautions: Women with liver and heart diseases should avoid Regestrone

Regestrone is manufactured by Novartis India Limited. The medicine is strictly prescription based and should not be consumed without consulting a medical practitioner. It can cause severe side effects such as enlargement of breasts, blurred vision, etc. Also, it is found to interact with other drugs and cause undesired effects on the fetus.

Uses and Benefits of Regestrone:

Apart from balancing the hormones in women, Regestrone 5 MG Tablet is also used for the treatment of certain other diseases as well.

Some of the well-known uses of Regestrone 5 MG Tablet are:

  • Treatment of endometrial cancer- It helps in the treatment of endometrial cancer. In endometrial cancer; the lining of tissue grows out of the uterus, which results in pain.
  • Treatment of the Abnormal uterine bleeding- Some women experience heavy or prolonged bleeding during their menstrual cycle. The consumption of Regestrone 5 MG Tablet helps in prevention of abnormal uterine bleeding.
  • Treatment of the Amenorrhea- Amenorrhea is the absence of menstrual periods. Regestrone assists in resuming the menstrual periods.
  • As a contraceptive- It is used as an oral contraceptive medicine to avoid unwanted pregnancy.
  • Treatment of the premenstrual syndrome- Symptoms of premenstrual syndrome (PMS) are usually experienced between ovulation and the onset of menstrual period. The symptoms of premenstrual cycle include water retention, headache, breast pain, mood disturbances, etc. It  is prescribed to patients to help them get relief from the symptoms.
  • Treatment of breast cancer- It is used in the treatment of certain types of breast cancer.
  • Relaxing menstrual cramps- It is prescribed to provide relief from menstrual cramps. However, it should be consumed after consulting a medical practitioner.
  • Delaying of Periods- It helps in regulating irregular periods as well as delaying the periods, if needed.

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Side Effects of Regestrone:

Apart from the intended effects, the consumption of Regestrone 5 MG Tablet might result in some undesired effects. The effects may vary from person to person depending on the health condition, age, ongoing drugs, etc.

Here is a list of side-effects that may be observed after consuming Regestrone:

  • Trouble sleeping (Moderate and Common)
  • Facial Hair Growth (Minor and Common)
  • Enlargement of breasts (Moderate and Less Common)
  • Irregular Menstrual Periods (Moderate and Less Common)
  • Acneiform eruptions (Common and Minor)
  • Weight Loss or Gain (Minor and Less Common)
  • Migraine-like Headaches (Common and Moderate)
  • Blood is seen in a cough (Major but rare)
  • Bulging of Eyes (Less Common and moderate)
  • Difficulty in breathing (Major but very less common)
  • Yellowing of eyes or skin (Less common but major)
  • Allergic skin eruptions (Less common and Moderate)

The patient should share the medical history in advance with the medical practitioner prescribing Regestrone in order to avoid occurrence of side effects. Also, in case any side effect is experienced; a medical practitioner should be consulted immediately.

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Common Dosage of Regestrone:

The Medicine  should be taken only after consulting a medical practitioner. The dosage and duration of the course of Regestrone depends on the medical condition, its severity and age of the women.

The usual schedule and dose of the medicine specific to conditions is listed below:

  • To delay periods: The Medicine should be started three days prior to the due date of the menstrual cycle. It is advised to consume Regestrone for up to 14 days or till the time the periods are to be delayed. The woman will get her periods within 2-3 days once the consumption of the medicine is discontinued.
  • To treat heavy periods: If a woman is experiencing heavy bleeding continuously, then it is advised to consume a 5 mg tablet thrice a day for 10 days. This helps in the prevention of excessive bleeding. Usually, bleeding stops within first 3 days but the tablet should be continued for 10 days. However, if bleeding continues then a medical practitioner should be consulted. Also, to prevent heavy periods a woman should consume the Tablet twice a day, specifically between 19th to 26th days of the cycle. The course is usually recommended for two months by a medical practitioner.
  • To treat painful periods: A tablet of 5 mg should be consumed thrice a day from 5th to 24th days of the menstrual cycle. The course is usually recommended for 3-4 months.
  • For treatment of endometriosis: In case of endometriosis, This should be consumed for 4-6 months. Course of the the drug  should be started from the 5th day of the menstrual cycle. Bleeding stops during the course of Regestrone; however if any blood spot is observed then a medical practitioner should be consulted for dose adjustment.

In case a dose is missed, This Medicine should be consumed as soon as one remembers about it. However, if it is the time for the next dose, it is advised to continue with the usual schedule instead of overdosing.

In any case, overdosing on Regestrone must be avoided as it may result in undesired effects such as nausea, vaginal bleeding, etc. If a woman overdose on the Tablet, a doctor must be consulted without any delay.

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Composition & Nature of Regestrone:

There is only one major component of Regestrone i.e. Norethisterone. The ingredient belongs to a group of medicine called Progestogens. The action of Regestrone is similar to progesterone (a female hormone). The ingredient is chemically synthesized.

Regestrone 5 MG Tablet when taken at different days of the menstrual cycle can control the development and shedding of the womb lining. The medicine is effective in delaying the menstrual cycle, relieving pain at the time of periods, and regulating irregular and heavy periods. It helps in minimizing the severity of premenstrual syndrome (PMS) and endometriosis.

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Regestrone Price in India:

Medicine Price
Regestrone (5 mg) INR 51.97/ (Strip of 10 tablets)
Regestrone (10 mg) INR 180/ (Strip of 10 tablets)
Regestrone (15 mg) INR 114.6 (Strip of 5 tablets)

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How to take the Regestrone?

  • It should be swallowed whole with water. In any case, the medicine should not be chewed.
  • It should not be crushed or broken before its consumption.
  • The medicine should be consumed as per the dosage prescribed by a medical practitioner.
  • It is advised not to share the medicine with an individual having similar symptoms.
  • The medicine should be consumed only after consuming a meal. Failing to do so may result in acid reflux.
  • Once the medicine is discontinued, a woman may experience irregular or no period for a while. However, it is advised to go for a pregnancy test to be on the safer side.

How Regestrone 5 MG Tablet works?

The functionality of this medicine is quite simple. The Norethisterone, which is an equivalent of the progesterone, suppresses the production of natural progesterone and estrogen. This controls the ovulation and ultimately control the birth process. The discontinuation of the medicine dose makes the periods irregular for some time. As it causes acid reflux with an empty stomach, it is always advised to consume Regestrone only after eating a meal.

Warnings/Precautions- When to avoid Regestrone?

It is advised to refrain from self-medication. It is important to exercise caution while consuming Regestrone. Some of the precautions that should be kept in mind are:

  • It should not be consumed by pregnant women as it may cause undesired effect on the fetus.
  • The medicine should not be consumed by women who are allergic to Regestrone 5 MG Tablet or any of its ingredients.
  • It is not recommended for women who smoke, as it increases the risk of severe heart diseases.
  • It is advised not to combine oral contraceptives; doing so increases the risk of developing liver tumors.
  • Women experiencing an irregular menstrual cycle or vaginal bleeding should avoid the use of Regestrone.
  • Use of Regestrone may increase the level of glucose in the body.
  • This medicine may decrease the level of thyroxine in the body. Thyroxine is a hormone which plays a vital role in digestion, muscle function, heart function, and brain development and in the maintenance of bones.
  • Use of the tablet can alter the level of cholesterol in the body, which in turn can affect the functioning of the heart. It may also result in heart disease.
  • It is advised to not use Regestrone 5 MG Tablet while breastfeeding as it may pass into breast milk and affect the newborn.
  • If a woman is trying to conceive, then a doctor should be consulted in advance as it may interfere with the process.
  • It is not safe to drive or operate heavy machinery after consuming Regestrone; as Regestrone is known to causes dizziness.
  • In case of liver or arteries related conditions.
  • In case of an ovarian cyst.
  • In case of porphyria or lupus erythematosus
  • In case the patients have or had breast cancer.
  • In case patients are taking other medicines.

Substitutes for Regestrone:

There are a number of substitutes available in the market for Regestrone 5 MG Tablet, which has the same composition and nature as that of Regestrone. Let us enlist a few major substitutes of the medicine:

  • Gynaset (Mankind Pharmaceuticals)
  • Covafem (Zuventus Healthcare)
  • Norglen (Glenmark Pharmaceuticals)
  • Dubogen (Unichem Lab)
  • Norgest (Micro Labs)

Regestrone 5 MG Tablet Interactions:

This drug is not free of drug interaction. If a woman consumes Regestrone with certain foods, medicine or drink, there are potential risks of drug interaction. The interaction of Regestrone 5 MG Tablet is observed in the following cases.

Interaction with drugs:

Regestrone when taken along with certain medicines may show certain undesired effects or worsen the present clinical conditions. Here is a list of drugs with which this medicine may show interactions:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Drugs belonging to this category are used to relieve pain and reduce fever. NSAIDs when combined along with Regestrone can result in fluid retention, thus causing swelling of the body parts.
  • Anticonvulsants: Carbamazepine and Phenytoin are some of the drugs which belong to the category of anticonvulsants and are used in the treatment of seizures. These drugs tend to reduce the effectiveness of Regestrone, when combined.
  • Anti-infective: It is used in the treatment of infections such as tuberculosis. Anti-infective medicines when combined with Regestrone may reduce its effectiveness.
  • Anti-viral agents: These drugs are used in the treatment of viral infections. Anti-viral drugs when combined along with drug can decrease the effectiveness of Regestrone.
  • Cytotoxic drug: The drug is used in the treatment of cancer. Regestrone 5 MG Tablet can hamper the working of cytotoxic drugs and hence, impact the cancer treatment. It is advised to consult a medical practitioner to avoid any such complications.
  • Aromatase inhibitors: This category of drug is used in the treatment of prostate cancer, breast cancer, seizures and hormonal disorder which is also termed as Cushing’s syndrome. Use of aromatase inhibitors reduces the level of Regestrone in the body.
  • Immunosuppressants: The drug is used to suppress the immune system of the body. This makes the body less likely to reject a transplanted organ. Consumption of cyclosporin may reduce the level and effectiveness of Regestrone in the body.
  • Herbal supplements: Any herbal supplements intended for the treatment of anxiety, depression or skin disorders can interact with Regestrone 5 MG Tablet. The herbal supplements can reduce the effectiveness of Regestrone. The list of drugs mentioned above is not exclusive. Hence, it is advised to discuss all the ongoing medicines with a medical practitioner to avoid any kind of complications. Also, if any complication is being experienced then a doctor should be consulted immediately and the dosage should be adjusted. In case the condition gets worse or Regestrone 5 MG Tablet becomes ineffective, the ongoing medicine should be replaced with a suitable alternative.

Interaction with Alcohol:

It is advised not to consume alcohol with Regestrone. Combining the medicine with alcohol can cause sleepiness and dizziness.

Interaction with Diseases:

Regestrone, when taken in case of certain disease, can worsen the present condition or may result in some undesired effects. Listed below are the diseases with which Regestrone interacts.

  • Depressions: Use of the medicine can worsen the depression. It is advised to use the drug with caution if a woman has a history of depression.  Also, the patient should be kept under constant observation.
  • Edema and Fluid retention: Use of the medicine can cause fluid retention in the body. Regestrone should be taken with caution by patients suffering from fluid retention disorder or any similar risk factors.
    It is advised to seek medical attention if any undesired effect is experienced.
  • Hepatic neoplasms: Use of the medicine is not advisable in case of patients suffering from a liver tumor. It is advised to use Regestrone with caution as the risk of adverse effect is very high.
  • Retinal thrombosis: Consumption of the Tablet can cause problems with the vision as well as other concerns in the eyes. Regestrone should be used with extreme caution in a patient with a history of eye disease. Use of Regestrone should be stopped immediately if any visual disturbance is being experienced.
  • Liver diseases: The medicine should be used with caution by patients suffering from liver disease or with a history of the same. Pulmonary embolism and Vein thrombosis: Regestrone should be used with caution by patients suffering from or with a history of blood clots in the arteries and veins of the lungs.

Lab test:

Presence of Regestrone 5 MG Tablet in the body may interfere with the test result of some lab tests. It is advised to inform the lab practitioner in advance about the consumption of Regestrone. Use of Regestrone may interfere with the result of Thyroid function test.

Medicines that should not be taken with Regestrone:

  • Rifampicin
  • Rifabutin
  • Ampicillin
  • Aspirin
  • Carbamazepine
  • Phenytoin
  • Ibuprofen
  • Ritonavir
  • Nelfinavir
  • Aminoglutethimide
  • Cyclosporin
  • Clarithromycin
  • Divalproex
  • Tranexamic Acid
  • Aminophylline
  • Mycophenolate Mofetil
  • Insulin
  • Griseofulvin
  • Phenobarbital

How to store Regestrone 5 MG Tablet?

  • It should not be stored below 25 °C. Furthermore, the medicine should not be kept in the refrigerator.
  • This should be kept away from the reach of children and pets.
  • It should not be exposed to direct heat and light.
  • The medicine should not be poured in the drain or flushed as it may contaminate the environment.
  • If the drug is expired, then it should be disposed properly. A pharmacist should be consulted for disposal information.

FAQs

1) For how long does Regestrone 5 MG Tablet show effect on the body?

Ans: Actually, the effect depends on the quantity consumed and the use for which it is intended. So there is no definite answer for it. It is advisable to consult a doctor before consuming Regestrone 5 MG Tablet.

2) After how long does Regestrone 5 MG Tablet starts to work?

Ans: Well, it varies from person to person, and it also depends on the hormones level present in the body.

3) Is it safe to use Regestrone 5 MG Tablet during or after the pregnancy?

Ans: No, it is not to be used by the pregnant or planning to be pregnant ladies. If any pregnancy occurs while taking Regestrone, you need to consult your doctor about it.

4) Is the nature of Regestrone addictive?

Ans: No, the nature of Regestrone 5 MG Tablet is not reported to be addictive by anyone.

5) Is Regestrone 5 MG Tablet meant for men also?

Ans: No, not really. As it is associated with the periods of women. It is not advised to be used by men or children.

6) How does Regestrone 5 MG Tablet lines the menstrual cycle?

Ans: As Regestrone 5 MG Tablet has progestin (a female hormone), it somehow helps to regularize and align the uterus properly.

7) Does Regestrone cause tiredness?

Ans: Yes, many of the users have reported that they started feeling tired after taking Regestrone. So beware of it while taking Regestrone 5 MG Tablet.

8) Is driving safe after taking Regestrone 5 MG Tablet?

Ans: No, it is not commonly recommended. Every medicine makes some bodily changes. So if you feel tired, drowsy etc., you must not drive at all.

9) Does Regestrone cause miscarriage?

Ans: No, it is not reported till now.

10) Is there any role of Regestrone 5 MG Tablet in causing weight gain?

Ans: Yes, this is a reported side effect of Regestrone 5 MG Tablet. If there is an excessive weight gain, you must consult your doctor.

11) What are the side-effects of Regestrone?

Ans: Regestrone can produce some minor side effects like hirsutism, skin reaction, nausea, voice changes, increased weight, acne, irregular menstrual bleeding, dizziness etc.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

User Comments (1)

S

Sweety

Sun Mar 31 2019

I used tablet to postpone d periods bt it doesn't work n got my periods & after Dat again I got normal bleeding within 15 days.... Bt now 1mn 8days passed I have not get my periods n enfact I checked pregnancy test also its negative.....Bt my stomach pain daily... What may b reasons??

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