Rifagut 400 MG Tablet: Uses, Side Effects, Composition & Dosages

Rifagut 400mg Tablet is a non-aminoglycoside semi-synthetic antibiotic drug. Along with Irritable Bowel Syndrome and Hepatic Encephalopathy (loss of brain function when toxins are not eliminated from the blood due to Liver Dysfunction), the drug is also used in the treatment of traveler’s diarrhea caused due to certain strains of bacteria especially E.coli bacteria.

Nature of Rifagut 400 MG Tablet: Antibiotic
Composition of Rifagut 400 MG Tablet: Rifaximin
Uses of Rifagut 400 MG Tablet: Irritable bowel syndrome , Liver failure, Traveler’s Diarrhea
Side-effects of Rifagut 400 MG Tablet: Dizziness , Black stools, Chest pain
Precautions of Rifagut 400 MG Tablet: Dental Procedures, Pregnancy, Breastfeeding, Surgeries
Rifagut 400 MG Tablet

Uses and benefits of Rifagut 400 MG Tablet:

Listed below are the conditions or symptoms that can be treated using Rifagut 400 MG Tablet:

  • Irritable Bowel Syndrome associated Diarrhea
  • Liver failure
  • Bacterial Infections of the intestines
  • Liver damage
  • Hepatic Encephalopathy
  • Traveler’s Diarrhea

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Side Effects of Rifagut 400 MG Tablet:

Almost all drugs come with a list of side effects and so does Rifagut 400 MG Tablet. Following are the side effects observed during therapy with Rifagut 400:

Major side effects:

  • Dizziness
  • Appearance of blood in the urine
  • Difficulty in breathing
  • Black or tarry stools
  • Chest pain

Minor side effects:

  • Swelling of face, tongue, hands, and feet
  • Pain in the Joints
  • Convulsions
  • Swelling of ankles
  • Stomach Cramps
  • Ulcer and sore throat
  • Flatulence
  • Headache
  • Fever

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Common Dosage of Rifagut 400 MG Tablet:

One must follow doctor’s instructions for proper dose and duration of administration. Rifagut 400 must not be crushed or chewed. It must be swallowed as a whole. Also, it must not be broken at the time of consumption. Rifagut 400 mg tablet can be taken with or without food. It is beneficial to take Rifagut 400 at a fixed time.

Rifagut 400 is prescribed on the basis of age, sex and severity of the conditions. In case of a missed dose, Rifagut 400 should be taken as soon as possible. If it is coinciding with the time of next dose, then the regular schedule should be followed and the missed dose must be skipped. In case of an overdose, it is advised to seek medical help immediately.

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Composition and Nature of Rifagut 400 MG Tablet:

Rifagut 400mg Tablet consists of Rifaximin (400mg) as its active ingredient. Rifaximin is a site-specific antibiotic.

Precaution and Warning - When to Avoid Rifagut 400 MG?

  • If Rifagut 400 is being consumed as an over-the-counter medicine, then all the details must be discussed with a pharmacist.
  • It is advised to read the ingredients/salts before consuming Rifagut 400. The medicine must not be consumed if an individual is allergic to Rifagut 400 or any of its ingredients.
  • Before consuming Rifagut 400, health condition or medical history of the patient must be discussed in advance with the medical practitioner.
  • Rifagut 400 mg may decrease the efficiency or neutralize the effect of bacterial vaccines including typhoid vaccine.
  • It is advised not to undergo any vaccinations or immunizations while using Rifagut 400 mg, unless asked by a medical practitioner.
  • Before undergoing any surgery or dental procedures, the medical procedure must be informed in advance about the use of Rifagut 400.
  • Rifagut 400 should be avoided by pregnant women. In any case, risks and benefits should be discussed with a medical practitioner.
  • Breastfeeding women should consume Rifagut 400 after weighing risks and benefits. The interaction is unknown.

Substitutes for Rifagut 400 MG tablet:

There are substitutes available for Rifagut 400 mg Tablet with the same content and concentration of the active ingredient. The substitutes for Rifagut 400 are as follows:

  • Torfix 400mg Tablet manufactured by Torrent Pharmaceuticals Ltd.
  • Rixmin 400mg Tablet manufactured by Cipla Ltd.
  • Dirifa 400mg Tablet manufactured by Abbott.
  • Rifastop 400mg Tablet manufactured by Mankind Pharma Ltd.
  • Sibofix 400mg Tablet manufactured by Dr. Reddys Laboratories Ltd.
  • Rcifax 400mg Tablet manufactured by Lupin Ltd.

Rifagut 400 mg Tablet Interaction with Other Drugs:

Rifagut 400 when taken along with some drugs, food items and in case of certain diseases can worsen the existing conditions or cause some undesired effects. Hence, it is advised to use the medicine after consulting a doctor.

Here is a list of certain reported interactions:

Drug interactions

Rifagut 400 when taken along with certain drugs may result in neutralization of effect of either of the medicines or lead to unwanted effects.

Here is list of drugs that should be avoided:

  • Ketoconazole
  • Propranolol
  • Warfarin
  • Cyclosporine
  • Live Cholera Vaccine
  • Ibrutinib
  • Rolapitant
  • Pantoprazole

Disease interaction

Rifagut 400 should not be consumed when suffering from pre-existing medical conditions as it may result in worsening of the existing condition or may result in some side effects.

Here is a list of diseases when Rifagut 400 should be avoided:

  • Colitis: The medicine should be used with extreme caution in patients suffering from colitis or other gastrointestinal tract, as it may worsen the disease. Also, the medicine should be stopped if the patient experiences diarrhea for longer time.
  • Liver diseases: The medicine should be used with extreme caution by patients with liver diseases.

Rifagut 400 MG Tablet Price in India:

Medicine Price
Rifagut 400 INR  260 (per strip of 10 tablets)

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How Rifagut 400 MG tablet works?

Rifagut 400 mg tablet is an antibiotic that destroys or inhibits the growth of microorganisms. It acts on the gastrointestinal tract by killing and stopping the growth of ammonia-producing bacteria known as E.coli. Thus, it reduces the production of ammonia.

How to Use Rifagut 400 MG Tablet?

  • In order to mitigate antibiotic resistance and increase the efficiency of Rifagut 400, it is suggested that all antibacterial therapies should be chosen based on susceptibility tests and bacterial culture.
  • Dosage must be scheduled according to need of the patient, severity of the condition and type of infections.
  • Rifagut 400 are absorbed well when administered orally.
  • The tablet must be swallowed as a whole. It should not be chewed or broken before consuming.
  • The tablet can be taken with or without food. It is advised to ask a doctor regarding the same.
  • Rifagut 400 must be consumed at even intervals so that some amount of drug is present in the body all the time.
  • It is advised to complete the course of Rifagut 400 as leaving the medicine in middle of the course may result in decreased efficiency of the drug. It also increases the risk of development of antibiotic resistant bacteria, thus making it inefficient for future purpose.

How to Store Rifagut 400?

  • Rifagut 400 should not be exposed directly to heat and light.
  • Rifagut 400 MG Tablet should be kept in tightly packed container.
  • The placed of storage should be away from the reach of children and pets.
  • Rifagut 400 should not be stored in refrigerator.

Frequently Asked Questions

1) Can Paracetamol be administered with Rifagut 400?

Ans: Yes. Paracetamol can be administered along with Rifagut 400 as no interactions have been clinically observed between the two of them.

2) Does the color of urine change to orange while administering Rifagut 400?

Ans: Yes. Rifagut Tablet may cause an orange discoloration of the urine.

3) Is Rifagut 400 MG Tablet and Antibiotic?

Ans: Yes. Rifagut 400 mg Tablet is an Antibiotic drug. It is site specific and used in the treatment of Irritable Bowel Syndrome, Hepatic Encephalopathy, and Traveler’s Diarrhea. The drug is active only against E.coli bacteria effectively.

4) Is Rifagut 400 tablet a safe drug?

Ans: Yes. Rifagut Tablet is a safe drug. However, it comes with its own list of side effects; hence it should be administered only in the dose and duration as prescribed by the Doctor.

5) Does Rifagut 400 Tablet cause Diarrhea?

Ans: Yes. Diarrhea is a common side effect experienced during therapy with Rifagut 400. However, if you experience severe Diarrhea then stop Rifagut 400 and immediately inform your Doctor.

6) Can treatment with Rifagut 400 be stopped immediately?

Ans: No. If treatment with Rifagut 400 is stopped immediately it will have a rebound effect. The bacteria will become drug resistant and the same drug may not be used to treat the infection again.

7) Is Rifagut 400 a banned drug in India?

Ans : No, Rifagut is not banned in India. You can even get it over the counter with or without any prescription yet, it is advisable to not consume the drug without consulting the doctor.

8) Does the dosage of Rifagut 400 vary patient to patient?

Ans: Yes, the dosage of Rifagut varies patient to patient. A few factors that decide the dosage are:

  • Age of the patient
  • Weight of the patient
  • Combination with other medicines
  • Type of infection
  • Other health concerns like liver diseases, pregnancy, blood pressure , etc.

9)  What to do if an expired dosage of Rifagut 400 Tablet is consumed?

Ans: Read the label carefully and always check for expiry date before consuming any medicine. However, if accidentally an expired dosage of Rifagut is consumed then visit your doctor to seek appropriate remedies.

10) What are the maximum and minimum dosages of Rifagut 400 tablet?

Ans: Minimum and maximum dosage of Rifagut 400 varies from patient to patient. For an adult, the maximum permissible dosage is 550 mg per day. However, the dosage varies with the type of the infection to be treated and health conditions of an individual.

11) Can I take Rifagut 400 to cure cold and cough?

Ans: No, Rifagut 400 is an antibiotic which treats only bacterial infections. Since cold and cough are caused due to viral infections, this bactericidal drug will not show the desired result.

12) When Rifagut 400 should be avoided?

Ans: Rifagut 400 should be avoided in following circumstances:

  • If an individual is allergic to Rifagut 400 or any of its ingredients
  • If an individual is suffering from any kind of liver impairment
  • If cause of Traveller’s diarrhea is not caused because of E.coli bacteria
  • If diarrhea is associated with clostridium difficile (bacteria)
  • If bacteria is resistant to Rifagut 400

13) Is there any side-effect of Rifagut 400 Tablet?

Ans: Yes, apart from the intended affect Rifagut 400 tablet shows side effects as well. Here is a list of side effects reported by some of the patients:

  • Nausea
  • Vomiting
  • Dizziness
  • Black/ green stools
  • Bloating
  • Stomach upset
  • Sleep disorder
  • Fatigue
  • Confusion
  • Headache

14) Can an on-going treatment with Rifagut 400 mg Tablet be stopped immediately?

Ans: No, if treatment with Rifagut Tablet is stopped immediately it will have a rebound effect. The bacteria will become drug resistant and the same drug may not be used to treat the infection again.

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Last updated on : 26-09-2019

Disclaimer : Docprime doesn’t endorse or take any guarantee of the accuracy or completeness of information provided under this article and these are the views strictly of the writer. Docprime shall not be held responsible for any aspect of healthcare services administered with the information provided on this article.

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